Dixar-Plus
Generic Name
dixar-plus-20-mg-syrup
Manufacturer
Opso Saline Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dixar plus 20 mg syrup | ৳ 110.00 | N/A |
Description
Overview of the medicine
Dixar-Plus 20 mg Syrup is an antiemetic and prokinetic agent used to relieve nausea, vomiting, and discomfort associated with slow stomach emptying or gastroesophageal reflux disease (GERD). It works by blocking dopamine receptors, which helps to increase movement through the digestive system.
Uses & Indications
Dosage
Adults
For dyspepsia: 10-20 mg (5-10 ml) three times daily, 15-30 minutes before meals and, if necessary, before bedtime. Maximum 80 mg/day. For nausea/vomiting: 10-20 mg (5-10 ml) three to four times daily. Maximum 80 mg/day.
Elderly
Similar to adult dosage, but caution advised. Lower doses or reduced frequency may be considered due to potential reduced renal/hepatic function.
Renal_impairment
Dosage frequency should be reduced to once or twice daily, depending on severity of impairment (e.g., every 12-24 hours for severe impairment).
How to Take
Take orally, 15-30 minutes before meals. Do not exceed recommended dose. For accurate dosing, use the provided measuring cup or spoon.
Mechanism of Action
Domperidone acts as a peripheral dopamine D2 and D3 receptor antagonist. It increases lower esophageal sphincter tone, improves gastroduodenal motility and peristalsis, thereby accelerating gastric emptying and reducing small bowel transit time. Its antiemetic effect is due to blockade of dopamine receptors in the chemoreceptor trigger zone (CTZ), located outside the blood-brain barrier.
Pharmacokinetics
Onset
15-30 minutes
Excretion
About 66% excreted in feces and 33% in urine, mostly as metabolites.
Half life
Approximately 7-9 hours (prolonged in severe renal impairment)
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations occur within 30-60 minutes. Bioavailability is low (about 15%) due to extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver via N-dealkylation and oxidative hydroxylation, primarily by CYP3A4.
Side Effects
Contraindications
- •Known hypersensitivity to Domperidone or any component of the formulation
- •Patients with pituitary prolactinoma
- •Patients with moderate to severe hepatic impairment
- •Patients with conditions where gastrointestinal stimulation could be harmful (e.g., gastrointestinal hemorrhage, mechanical obstruction or perforation)
- •Concomitant use with QT-prolonging drugs or potent CYP3A4 inhibitors
Drug Interactions
Anticholinergics
May antagonize the prokinetic effect of Domperidone.
Ketoconazole, Erythromycin, Clarithromycin
Increased risk of QTc prolongation due to CYP3A4 inhibition.
Proton Pump Inhibitors (PPIs) / H2 Blockers
May reduce the bioavailability of Domperidone, take Domperidone before food.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include drowsiness, disorientation, extrapyramidal reactions (e.g., involuntary muscle movements). Treatment is symptomatic and supportive. Gastric lavage may be useful within one hour of ingestion. Anticholinergic, antiparkinsonian drugs may help control extrapyramidal reactions.
Pregnancy & Lactation
Pregnancy Category C: Use only if clearly needed. Small amounts are excreted in breast milk, caution advised in nursing mothers. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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