Dizuva
Generic Name
Desvenlafaxine
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dizuva 1 mg capsule | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Dizuva 1 mg Capsule contains Desvenlafaxine, an antidepressant primarily used to treat major depressive disorder. It belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs), which work by increasing the levels of serotonin and norepinephrine in the brain. Please note that Desvenlafaxine is typically available in higher strengths (e.g., 50 mg, 100 mg), and a 1 mg formulation is atypical for its standard indications.
Uses & Indications
Dosage
Adults
Typically, the recommended starting dose of Desvenlafaxine is 50 mg once daily. Depending on patient response and tolerability, the dose may be increased to 100 mg once daily. If using Dizuva 1 mg capsules, this would equate to 50 or 100 capsules per day, respectively. Consult a physician for specific dosage.
Elderly
Elderly patients generally do not require dose adjustment based on age alone; however, caution is advised due to potential for renal impairment. A lower starting dose or slower titration may be considered. If using Dizuva 1 mg capsules, this would equate to 50 or 100 capsules per day, respectively.
Renal_impairment
For patients with moderate renal impairment (CrCl 30 to 50 mL/min), the recommended dose should not exceed 50 mg per day. For severe renal impairment (CrCl <30 mL/min), the recommended dose is 50 mg every other day. If using Dizuva 1 mg capsules, this would equate to 50 capsules daily or 50 capsules every other day, respectively.
How to Take
Take the capsule whole with or without food, at approximately the same time each day. Do not crush, chew, or dissolve the capsule.
Mechanism of Action
Desvenlafaxine selectively inhibits the reuptake of both serotonin and norepinephrine in the brain, thereby increasing the availability of these neurotransmitters in the synaptic cleft. This leads to an antidepressant effect. It has a minimal affinity for muscarinic, histaminergic, or adrenergic receptors.
Pharmacokinetics
Onset
Antidepressant effects may take 2-4 weeks to become apparent.
Excretion
Primarily eliminated via the kidneys as metabolites and unchanged drug.
Half life
Approximately 9-13 hours.
Absorption
Well absorbed after oral administration; peak plasma concentrations reached in about 7.5 hours.
Metabolism
Primarily undergoes conjugation by UGT enzymes and oxidative metabolism by CYP3A4.
Side Effects
Contraindications
- Concomitant use with MAOIs or within 14 days of discontinuing MAOI treatment
- Hypersensitivity to desvenlafaxine or venlafaxine or any component of the formulation
Drug Interactions
Alcohol
Avoid alcohol due to potential for CNS depression and exacerbation of side effects.
MAO Inhibitors
Concomitant use is contraindicated due to risk of serious, sometimes fatal, reactions including serotonin syndrome.
Anticoagulants/Antiplatelets
Increased risk of bleeding.
Serotonergic drugs (e.g., SSRIs, triptans, fentanyl, lithium, tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store at room temperature (below 30°C) in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include tachycardia, changes in level of consciousness, mydriasis, seizures, and vomiting. Treatment is supportive and symptomatic; ensure adequate airway, oxygenation, and ventilation. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as desvenlafaxine is excreted in human milk. Consult a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA)
Patent Status
Generics available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of desvenlafaxine for major depressive disorder. Key studies involved placebo-controlled trials showing significant reductions in HAM-D scores. Long-term studies have also evaluated sustained efficacy and tolerability.
Lab Monitoring
- Blood pressure monitoring (especially at initiation and dose increases)
- Serum sodium levels (especially in elderly patients or those on diuretics)
- Lipid profile (baseline and periodically)
Doctor Notes
- Counsel patients on potential for increased suicidal thoughts/behaviors, especially at initiation or dose changes.
- Monitor blood pressure regularly.
- Assess for symptoms of serotonin syndrome when co-administered with other serotonergic agents.
- Emphasize gradual discontinuation to avoid withdrawal symptoms.
Patient Guidelines
- Take as directed by your doctor, do not stop abruptly.
- Report any unusual mood changes or suicidal thoughts.
- Avoid alcohol while on this medication.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, somnolence, or visual disturbances. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that desvenlafaxine does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Engage in regular physical activity.
- Maintain a balanced diet and adequate sleep.
- Practice stress-reduction techniques.
- Seek support from family, friends, or support groups.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.