Dobesil
Generic Name
Calcium Dobesilate 500 mg
Manufacturer
General Pharmaceutical Manufacturers
Country
Switzerland (originator), Global production
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dobesil 500 mg capsule | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Dobesil-500-mg-capsule contains Calcium Dobesilate, a vasoprotective agent used to treat microangiopathies, particularly diabetic retinopathy, and symptoms of chronic venous insufficiency.
Uses & Indications
Dosage
Adults
Usually 500-1000 mg daily, divided into 1-2 doses, with or after meals. Duration of treatment depends on the condition.
Elderly
No specific dose adjustment required, but caution should be exercised in patients with renal impairment.
Renal_impairment
In severe renal impairment requiring dialysis, a reduced dose may be necessary. Use with caution.
How to Take
Take orally, preferably with or after meals to minimize gastrointestinal discomfort.
Mechanism of Action
Calcium Dobesilate acts primarily by normalizing capillary permeability and resistance. It reduces increased vascular permeability, improves microcirculation, and decreases blood viscosity and platelet aggregation. It also strengthens capillary walls and improves lymphatic drainage.
Pharmacokinetics
Onset
Therapeutic effects typically observed after several weeks of continuous treatment.
Excretion
Mainly renal (about 50% unchanged) and fecal (about 50%) within 24 hours.
Half life
Approximately 5 hours.
Absorption
Well absorbed after oral administration. Peak plasma concentration reached within 6 hours.
Metabolism
Minimal metabolism, mainly excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Calcium Dobesilate or any excipients.
- Patients with pre-existing severe renal failure requiring dialysis (use with caution, dose adjustment may be needed).
Drug Interactions
Anticoagulants
Theoretical risk of increased bleeding, monitor carefully.
Other Vasoprotectives
No significant known interactions.
Storage
Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children. Do not store above 30°C.
Overdose
Limited data on human overdose. Treatment is symptomatic and supportive. Gastric lavage may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved (varies by country)
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated its efficacy in improving microcirculation and symptoms of venous insufficiency and diabetic retinopathy.
Lab Monitoring
- Blood count monitoring (especially white blood cells) if fever or flu-like symptoms develop, due to the rare risk of agranulocytosis.
Doctor Notes
- Counsel patients on the importance of long-term adherence for optimal outcomes.
- Advise patients to seek immediate medical attention if they develop fever, sore throat, or signs of infection.
Patient Guidelines
- Take the capsule whole with water, do not chew or crush.
- Follow the prescribed dosage and duration of treatment.
- Report any unusual side effects, especially fever or sore throat, immediately to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, Calcium Dobesilate does not impair the ability to drive or operate machinery. However, if you experience dizziness or fatigue, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to support vascular health.
- Elevate legs and use compression stockings for chronic venous insufficiency as advised by a doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.