Dobesil LD
Generic Name
Dobesil LD
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dobesil ld 4 2 rectal ointment | ৳ 170.00 | N/A |
Description
Overview of the medicine
Dobesil LD is a medication containing Calcium Dobesilate, primarily used to treat microangiopathies, particularly diabetic retinopathy and chronic venous insufficiency. It strengthens blood vessel walls and reduces capillary permeability.
Uses & Indications
Dosage
Adults
500-1000 mg daily, usually divided into 1-2 doses after meals. Duration of treatment depends on the condition.
Elderly
No specific dosage adjustment required, but caution is advised in patients with severe renal impairment.
Renal_impairment
Consider dosage reduction in severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
To be taken orally, preferably after meals, with water.
Mechanism of Action
Calcium dobesilate acts on the capillary walls, reducing their permeability and improving their resistance. It inhibits certain enzymes involved in inflammation and microcirculatory disturbances, thus protecting endothelial cells and reducing blood viscosity.
Pharmacokinetics
Onset
Clinical effects usually observed within 1-2 weeks of treatment initiation.
Excretion
Mainly via urine, with some fecal excretion.
Half life
Approximately 5 hours.
Absorption
Rapidly but incompletely absorbed from the gastrointestinal tract. Peak plasma levels are reached within 6 hours.
Metabolism
Minimally metabolized. Primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Calcium Dobesilate or any excipients
- Severe renal insufficiency requiring dialysis
Drug Interactions
Anticoagulants
Potential to increase anticoagulant effect, monitor INR.
Storage
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended. Gastric lavage may be considered.
Pregnancy & Lactation
Use with caution; consult a doctor. Limited data available. Benefits should outweigh risks.
Side Effects
Contraindications
- Hypersensitivity to Calcium Dobesilate or any excipients
- Severe renal insufficiency requiring dialysis
Drug Interactions
Anticoagulants
Potential to increase anticoagulant effect, monitor INR.
Storage
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended. Gastric lavage may be considered.
Pregnancy & Lactation
Use with caution; consult a doctor. Limited data available. Benefits should outweigh risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 3 years from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials support its efficacy in microcirculatory disorders and venous diseases.
Lab Monitoring
- Complete blood count (CBC) if agranulocytosis is suspected.
- Renal function in patients with pre-existing kidney conditions.
Doctor Notes
- Advise patients on lifestyle modifications alongside medication for optimal results.
- Regular follow-up is important for diabetic retinopathy patients.
Patient Guidelines
- Follow your doctor's instructions carefully.
- Take the medicine regularly for the prescribed duration.
- Report any unusual side effects to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Maintain a healthy diet and regular exercise, especially for conditions like diabetic retinopathy.
- Avoid prolonged standing or sitting for venous insufficiency.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.