Docetax
Generic Name
Docetaxel 20 mg Injection
Manufacturer
Various Generic Manufacturers
Country
Global
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| docetax 20 mg injection | ৳ 3,500.00 | N/A |
Description
Overview of the medicine
Docetaxel is an antineoplastic agent (chemotherapy) belonging to the taxoid family. It is used in the treatment of various cancers, including breast cancer, non-small cell lung cancer, prostate cancer, gastric adenocarcinoma, and head and neck cancer. It works by interfering with cell division.
Uses & Indications
Dosage
Adults
Varies significantly based on the type of cancer and regimen. Typically 75 mg/m² or 100 mg/m² administered intravenously over 1 hour every 3 weeks.
Elderly
No specific dose adjustment generally required, but close monitoring for adverse effects is recommended.
Renal_impairment
No routine dose adjustment is recommended for patients with mild to moderate renal impairment. Data for severe impairment is limited.
How to Take
Administered as a 1-hour intravenous infusion. Premedication with oral corticosteroids (e.g., dexamethasone) is required before each dose to reduce hypersensitivity reactions and fluid retention.
Mechanism of Action
Docetaxel binds to free tubulin and promotes the assembly of microtubules into stable bundles while inhibiting their disassembly. This leads to the formation of stable, non-functional microtubules that prevent cells from progressing through the cell cycle, ultimately leading to cell death (apoptosis).
Pharmacokinetics
Onset
Rapid onset due to IV administration. Therapeutic effects manifest over treatment cycles.
Excretion
Primarily excreted in the feces (approximately 75%) as metabolites, with a small amount excreted in the urine (approximately 6%).
Half life
Triphasic elimination with a terminal half-life of 11.1 hours.
Absorption
Administered intravenously, so 100% bioavailability.
Metabolism
Extensively metabolized in the liver by the CYP3A4 isoenzyme of the cytochrome P450 system.
Side Effects
Contraindications
- Hypersensitivity to docetaxel or to any other component, including polysorbate 80.
- Neutrophil count < 1,500 cells/mm³.
- Severe liver impairment.
Drug Interactions
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir)
May increase docetaxel plasma concentrations, leading to increased toxicity.
CYP3A4 inducers (e.g., phenytoin, carbamazepine, rifampin, phenobarbital)
May decrease docetaxel plasma concentrations, reducing efficacy.
Storage
Store unopened vials at 2°C to 25°C (36°F to 77°F). Protect from light. Do not refrigerate the diluent.
Overdose
The anticipated complications of overdose include bone marrow suppression, peripheral neurotoxicity, and mucositis. Management involves supportive care including G-CSF for neutropenia.
Pregnancy & Lactation
Pregnancy: Category D. Can cause fetal harm. Avoid use during pregnancy. Advise women of childbearing potential to use effective contraception. Lactation: It is unknown whether docetaxel is excreted in human milk. Due to the potential for serious adverse reactions in breastfed infants, advise women not to breastfeed during treatment.
Side Effects
Contraindications
- Hypersensitivity to docetaxel or to any other component, including polysorbate 80.
- Neutrophil count < 1,500 cells/mm³.
- Severe liver impairment.
Drug Interactions
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir)
May increase docetaxel plasma concentrations, leading to increased toxicity.
CYP3A4 inducers (e.g., phenytoin, carbamazepine, rifampin, phenobarbital)
May decrease docetaxel plasma concentrations, reducing efficacy.
Storage
Store unopened vials at 2°C to 25°C (36°F to 77°F). Protect from light. Do not refrigerate the diluent.
Overdose
The anticipated complications of overdose include bone marrow suppression, peripheral neurotoxicity, and mucositis. Management involves supportive care including G-CSF for neutropenia.
Pregnancy & Lactation
Pregnancy: Category D. Can cause fetal harm. Avoid use during pregnancy. Advise women of childbearing potential to use effective contraception. Lactation: It is unknown whether docetaxel is excreted in human milk. Due to the potential for serious adverse reactions in breastfed infants, advise women not to breastfeed during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored unopened. Once diluted, stability may vary; refer to product specific guidelines.
Availability
Hospitals, Specialized pharmacies
Approval Status
FDA Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Docetaxel has been extensively studied in numerous Phase I, II, and III clinical trials across various cancer types, demonstrating efficacy and informing its current indications and dosing regimens. Ongoing trials continue to explore its use in new combinations and settings.
Lab Monitoring
- Complete Blood Count (CBC) with differential before each cycle and periodically thereafter.
- Liver function tests (ALT, AST, bilirubin, alkaline phosphatase) before each cycle.
- Renal function tests (creatinine, BUN) periodically.
- Monitor for signs of fluid retention (weight gain, edema).
Doctor Notes
- Premedication with oral corticosteroids is crucial to mitigate hypersensitivity and fluid retention.
- Closely monitor CBC, LFTs, and renal function. Adjust dose for neutropenia or severe non-hematologic toxicities.
- Counsel patients on potential peripheral neuropathy and advise prompt reporting of symptoms.
Patient Guidelines
- Report any signs of infection (fever, chills) immediately.
- Monitor for swelling or fluid retention.
- Report numbness, tingling, or weakness in hands or feet.
- Maintain good oral hygiene to prevent mucositis.
- Avoid contact with people who are sick or have infections.
Missed Dose Advice
Contact your healthcare provider immediately if you miss an appointment for your docetaxel infusion. Do not self-administer a missed dose.
Driving Precautions
Docetaxel can cause fatigue, dizziness, or visual disturbances. Patients should be advised not to drive or operate machinery if they experience these effects.
Lifestyle Advice
- Stay hydrated.
- Eat a balanced diet, preferably soft, bland foods if mucositis occurs.
- Get adequate rest.
- Avoid alcohol and tobacco.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Docetax Brand
Other medicines available under the same brand name
