Dolwin
Generic Name
Paracetamol
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dolwin 500 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Dolwin 500 mg tablet contains Paracetamol, which is a common pain reliever and fever reducer. It is used to treat mild to moderate pain, such as headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, and to reduce fever.
Uses & Indications
Dosage
Adults
Oral: 500 mg to 1 g (one to two 500 mg tablets) every 4-6 hours as needed, not exceeding 4 g in 24 hours.
Elderly
No specific dose reduction is typically required for elderly patients, but caution is advised in those with impaired renal or hepatic function.
Renal_impairment
Dose interval should be extended in severe renal impairment (e.g., Creatinine Clearance < 10 mL/min). Consult a physician.
How to Take
Take the tablet orally with or without food. Swallow with a glass of water. Do not crush or chew if it's an extended-release form (though not applicable for this 500mg standard tablet).
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system, increasing the pain threshold by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are involved in prostaglandin synthesis. It also acts on the hypothalamic heat-regulating center to produce antipyresis.
Pharmacokinetics
Onset
Analgesia: 30-60 minutes; Antipyresis: 30-60 minutes.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1-3 hours in adults; slightly longer in neonates and patients with hepatic or renal impairment.
Absorption
Readily and completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 10-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation. A small portion is metabolized by cytochrome P450 into a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is rapidly detoxified by conjugation with glutathione.
Side Effects
Contraindications
- •Known hypersensitivity to Paracetamol or any other component of the tablet.
- •Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increased risk of liver toxicity.
Cholestyramine
Reduces the absorption of Paracetamol if taken within one hour.
Other hepatotoxic drugs
Increased risk of liver damage when taken concomitantly.
Warfarin and other oral anticoagulants
Increased anticoagulant effect, leading to a higher risk of bleeding, especially with prolonged use.
Phenobarbital, Carbamazepine, Phenytoin
May increase the metabolism of Paracetamol, reducing its effectiveness and potentially increasing toxic metabolite formation.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, and excessive sweating. Severe overdose can lead to hepatic necrosis, which may be fatal. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe during pregnancy and lactation at recommended doses, but always consult a doctor before use. Use the lowest effective dose for the shortest possible duration.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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