Domfix
Generic Name
Domperidone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| domfix 10 mg tablet | ৳ 2.50 | ৳ 37.50 |
Description
Overview of the medicine
Domperidone is an antiemetic and prokinetic drug. It is used to relieve nausea, vomiting, and certain stomach problems like dyspepsia and gastroparesis.
Uses & Indications
Dosage
Adults
10 mg three times daily, preferably 15-30 minutes before meals. Maximum recommended daily dose is 30 mg.
Elderly
Similar to adults, but caution advised due to potential cardiac risks. Lower dose may be considered.
Renal_impairment
Dose reduction necessary; 10 mg once or twice daily depending on severity. Avoid in severe renal impairment (CrCl < 30 mL/min).
How to Take
Take orally, preferably 15-30 minutes before meals. Do not chew, crush, or break the tablet.
Mechanism of Action
Blocks dopamine D2 receptors primarily in the chemoreceptor trigger zone (CTZ) and peripherally in the gastrointestinal tract, leading to antiemetic and prokinetic effects.
Pharmacokinetics
Onset
Within 30 minutes for antiemetic effects.
Excretion
Mainly in feces (66%) and urine (33%) as metabolites.
Half life
Approximately 7-9 hours (prolonged in renal impairment).
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations occur within 30-60 minutes. Bioavailability is low (15%) due to extensive first-pass metabolism.
Metabolism
Extensive hepatic metabolism by cytochrome P450 enzymes (mainly CYP3A4).
Side Effects
Contraindications
- Known hypersensitivity to domperidone or any excipients.
- Patients with prolactin-releasing pituitary tumor (prolactinoma).
- Moderate to severe hepatic impairment.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin).
- Patients with cardiac conduction prolongation (e.g., QTc prolongation), significant electrolyte disturbances or underlying cardiac diseases (e.g., congestive heart failure).
- Patients with gastrointestinal haemorrhage, mechanical obstruction, or perforation.
Drug Interactions
Dopamine agonists (e.g., bromocriptine, cabergoline)
Domperidone may antagonize their effects.
Antacids/Antisecretory agents (e.g., proton pump inhibitors)
May reduce oral bioavailability of domperidone. Administer domperidone before meals and these agents after meals.
Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, clarithromycin)
Increase domperidone plasma levels, significantly increasing cardiac risk (QT prolongation). Concomitant use is contraindicated.
QT-prolonging drugs (e.g., some antiarrhythmics, antipsychotics, certain antibiotics)
Add a risk of QT prolongation. Concomitant use is contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, disorientation, extrapyramidal reactions, and potentially cardiac arrhythmias. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks, after consulting a doctor. Avoid during lactation as domperidone is excreted in breast milk and may cause adverse effects in the infant.
Side Effects
Contraindications
- Known hypersensitivity to domperidone or any excipients.
- Patients with prolactin-releasing pituitary tumor (prolactinoma).
- Moderate to severe hepatic impairment.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin).
- Patients with cardiac conduction prolongation (e.g., QTc prolongation), significant electrolyte disturbances or underlying cardiac diseases (e.g., congestive heart failure).
- Patients with gastrointestinal haemorrhage, mechanical obstruction, or perforation.
Drug Interactions
Dopamine agonists (e.g., bromocriptine, cabergoline)
Domperidone may antagonize their effects.
Antacids/Antisecretory agents (e.g., proton pump inhibitors)
May reduce oral bioavailability of domperidone. Administer domperidone before meals and these agents after meals.
Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, clarithromycin)
Increase domperidone plasma levels, significantly increasing cardiac risk (QT prolongation). Concomitant use is contraindicated.
QT-prolonging drugs (e.g., some antiarrhythmics, antipsychotics, certain antibiotics)
Add a risk of QT prolongation. Concomitant use is contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, disorientation, extrapyramidal reactions, and potentially cardiac arrhythmias. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks, after consulting a doctor. Avoid during lactation as domperidone is excreted in breast milk and may cause adverse effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date when stored correctly.
Availability
Pharmacies and hospitals nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials established its efficacy for gastrointestinal motility disorders and antiemetic effects. Post-marketing surveillance continues to monitor cardiac safety, especially in specific populations.
Lab Monitoring
- ECG monitoring recommended in patients with cardiac risk factors, elderly, or those on prolonged therapy.
- Liver function tests in patients with hepatic impairment.
- Renal function monitoring in patients with renal impairment.
Doctor Notes
- Careful patient selection and adherence to recommended dosage for the shortest duration are crucial due to cardiac risks (QT prolongation).
- Monitor for signs of extrapyramidal symptoms, especially in children and young adults.
- Review concomitant medications for potential drug interactions, particularly CYP3A4 inhibitors and other QT-prolonging drugs.
Patient Guidelines
- Take exactly as prescribed by your doctor; do not alter the dose or duration of treatment.
- Do not exceed the recommended dose of 10 mg three times daily, or 30 mg per day.
- Report any unusual symptoms, especially heart palpitations, dizziness, or fainting, to your doctor immediately.
- Do not take this medicine for more than one week without consulting your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. Do not double the dose to make up for a missed one.
Driving Precautions
Domfix 10 mg Tablet may cause drowsiness, dizziness, or blurred vision in some individuals. Avoid driving or operating heavy machinery if you experience these effects.
Lifestyle Advice
- If you experience digestive issues, try eating small, frequent meals rather than large ones.
- Avoid fatty, spicy, and acidic foods that can worsen symptoms.
- Limit alcohol and caffeine intake.
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