Domixon
Generic Name
Domperidone
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| domixon 10 mg tablet | ৳ 3.50 | ৳ 35.00 |
Description
Overview of the medicine
Domixon (Domperidone) is an antiemetic and prokinetic agent used to treat nausea, vomiting, and gastric motility disorders.
Uses & Indications
Dosage
Adults
10 mg three times daily, 15-30 minutes before meals. Max 30 mg/day.
Elderly
Same as adults, but caution advised due to potential for QT prolongation.
Renal_impairment
Dosage reduction may be necessary; consider 10 mg once or twice daily for severe impairment.
How to Take
To be taken orally, 15-30 minutes before meals. Do not chew or crush tablets.
Mechanism of Action
Domperidone acts by blocking dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) and in the stomach, increasing gastrointestinal motility and having an antiemetic effect.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Excreted primarily in feces (66%) and urine (33%) as metabolites.
Half life
7-9 hours (longer in severe renal impairment)
Absorption
Rapidly absorbed after oral administration, peak plasma levels reached within 30-60 minutes.
Metabolism
Extensive first-pass metabolism in the liver and intestinal wall via cytochrome P450 3A4.
Side Effects
Contraindications
- Known hypersensitivity to Domperidone
- Patients with prolactin-releasing pituitary tumor
- Patients with moderate to severe hepatic impairment
- Concomitant use with QT prolonging drugs or potent CYP3A4 inhibitors
Drug Interactions
QT prolonging drugs
Increased risk of cardiac arrhythmias. (e.g., some antiarrhythmics, antipsychotics, antidepressants)
Strong CYP3A4 inhibitors
Increased plasma levels of Domperidone, increasing risk of QT prolongation. (e.g., ketoconazole, erythromycin, clarithromycin)
Storage
Store below 30°C, protected from light and moisture.
Overdose
Symptoms include drowsiness, disorientation, extrapyramidal reactions. Treatment is symptomatic and supportive, gastric lavage, activated charcoal.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks. Avoid during lactation as Domperidone is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensively studied for its prokinetic and antiemetic effects, with ongoing research into cardiac safety.
Lab Monitoring
- ECG monitoring (for patients at risk of QT prolongation)
- Liver function tests (in patients with hepatic impairment)
Doctor Notes
- Caution in patients with pre-existing cardiac conditions or electrolyte imbalances.
- Review treatment duration; generally not recommended for long-term use.
- Advise patients on potential cardiac risks and symptoms to watch for.
Patient Guidelines
- Take before meals for best effect.
- Do not exceed recommended dose.
- Report any unusual heart symptoms to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; advise caution when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption.
- Maintain a balanced diet.
- Avoid activities requiring mental alertness if drowsiness occurs.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.