Dopac
Generic Name
dopac-100-mg-capsule
Manufacturer
Alpha Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dopac 100 mg capsule | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Dopac 100 mg capsule is used in the treatment of Parkinson's disease to relieve symptoms such as tremor, stiffness, and slow movement. It works by increasing dopamine levels in the brain.
Uses & Indications
Dosage
Adults
Initially 50-100 mg orally 2-3 times daily, gradually increasing every 2-7 days as tolerated up to a maximum of 800 mg/day.
Elderly
Similar to adult dosage, but titration may be slower, with close monitoring for side effects.
Renal_impairment
No specific dosage adjustment required, but close monitoring is advised due to potential accumulation of metabolites.
How to Take
Orally, preferably with food to reduce gastrointestinal upset, but high protein meals can reduce absorption. Swallow whole, do not chew or crush.
Mechanism of Action
Dopac acts as a prodrug that is converted to dopamine in the brain, replenishing dopamine levels in the substantia nigra, which are deficient in Parkinson's disease.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Primarily excreted via the kidneys as metabolites.
Half life
Approximately 1-3 hours (unmodified)
Absorption
Rapidly absorbed from the gastrointestinal tract; absorption can be affected by food.
Metabolism
Extensively metabolized by decarboxylation in the periphery and in the brain.
Side Effects
Contraindications
- Hypersensitivity to Dopac or any component
- Narrow-angle glaucoma
- Concomitant use with non-selective MAO inhibitors
- Suspicious undiagnosed skin lesions or a history of melanoma
Drug Interactions
Metoclopramide
Increased GI upset, potential for reduced efficacy
Iron supplements
Reduced absorption of Dopac
Non-selective MAO inhibitors
Hypertensive crisis
Antipsychotics (D2 antagonists)
Reduced efficacy of Dopac
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include arrhythmias, hypotension, psychiatric disturbances, and muscle spasms. Treatment is supportive, including gastric lavage, activated charcoal, and monitoring vital signs.
Pregnancy & Lactation
Category C. Use only if potential benefit justifies the potential risk to the fetus. Excreted in breast milk; advise against breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired (generic available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials demonstrated efficacy and safety in patients with Parkinson's disease. Ongoing post-market surveillance.
Lab Monitoring
- Liver function tests
- Renal function tests
- Blood cell counts
- Intraocular pressure (in glaucoma patients)
Doctor Notes
- Advise patients about potential orthostatic hypotension and impulse control disorders.
- Monitor for psychiatric changes, especially in elderly patients.
- Gradual withdrawal is essential to avoid withdrawal syndrome.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor.
- Report any unusual movements or changes in mood to your doctor.
- Take with food to minimize stomach upset.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
May cause drowsiness or sudden onset of sleep. Exercise caution when driving or operating machinery. Avoid these activities if you experience these effects.
Lifestyle Advice
- Maintain a balanced diet, avoiding high protein meals close to dosing.
- Regular exercise as advised by your physician.
- Stay hydrated.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.