Dopair
Generic Name
Coenzyme Q10 / Ubidecarenone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dopair 100 mg tablet | ৳ 6.50 | ৳ 65.00 |
Description
Overview of the medicine
Coenzyme Q10 (CoQ10) is a vitamin-like substance naturally present in the body, primarily involved in cellular energy production in mitochondria and acting as a powerful antioxidant. It is used as a dietary supplement to support heart health, neurological function, and overall cellular energy.
Uses & Indications
Dosage
Adults
Typically 100-200 mg once or twice daily with food. Higher doses (e.g., 300-600 mg) may be used for specific conditions like heart failure or Parkinson's disease under medical supervision.
Elderly
Similar to adult dose; no specific adjustment typically needed.
Renal_impairment
No specific dosage adjustment required; CoQ10 is generally considered safe in renal impairment.
How to Take
Oral, preferably taken with a fatty meal to enhance absorption.
Mechanism of Action
CoQ10 functions as an electron carrier in the mitochondrial electron transport chain, which is crucial for ATP synthesis. It also acts as a potent lipid-soluble antioxidant, protecting cell membranes from oxidative damage by scavenging free radicals.
Pharmacokinetics
Onset
Gradual; clinical effects may take weeks to months to become apparent.
Excretion
Mainly excreted via biliary and fecal routes.
Half life
Highly variable, typically ranging from 30-36 hours for the ubiquinol form.
Absorption
Poorly absorbed, being lipophilic. Absorption is significantly enhanced when taken with fatty meals.
Metabolism
Primarily metabolized in the liver, with little information available on specific pathways.
Side Effects
Contraindications
- Hypersensitivity to Coenzyme Q10 or any component of the formulation.
Drug Interactions
Statins
Statins can deplete natural CoQ10 levels, so CoQ10 supplementation may be beneficial, though not a direct negative interaction.
Warfarin
May decrease the anticoagulant effect of warfarin, potentially increasing the risk of blood clots. Close monitoring of INR is recommended.
Blood pressure medications
May have an additive hypotensive effect; monitor blood pressure if taken concurrently.
Storage
Store in a cool, dry place, below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
CoQ10 is generally considered safe, even at high doses. No specific antidote exists. In case of suspected overdose, symptomatic and supportive care should be provided.
Pregnancy & Lactation
Limited data are available on CoQ10 use during pregnancy and lactation. It should be used with caution, only if clearly needed and the potential benefits outweigh the risks. Consult a healthcare professional.
Side Effects
Contraindications
- Hypersensitivity to Coenzyme Q10 or any component of the formulation.
Drug Interactions
Statins
Statins can deplete natural CoQ10 levels, so CoQ10 supplementation may be beneficial, though not a direct negative interaction.
Warfarin
May decrease the anticoagulant effect of warfarin, potentially increasing the risk of blood clots. Close monitoring of INR is recommended.
Blood pressure medications
May have an additive hypotensive effect; monitor blood pressure if taken concurrently.
Storage
Store in a cool, dry place, below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
CoQ10 is generally considered safe, even at high doses. No specific antidote exists. In case of suspected overdose, symptomatic and supportive care should be provided.
Pregnancy & Lactation
Limited data are available on CoQ10 use during pregnancy and lactation. It should be used with caution, only if clearly needed and the potential benefits outweigh the risks. Consult a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, check packaging for exact date.
Availability
Pharmacies, health stores
Approval Status
Generally recognized as safe (GRAS) for supplements; Approved as a supplement in Bangladesh.
Patent Status
Generic/Off-patent
Clinical Trials
Numerous clinical trials have investigated CoQ10 for various conditions, including heart failure, statin-induced myopathy, and hypertension, showing varying degrees of efficacy. More research is ongoing.
Lab Monitoring
- No routine laboratory monitoring is typically required for CoQ10 supplementation.
Doctor Notes
- Advise patients to take CoQ10 with food for optimal absorption.
- Emphasize careful monitoring for patients on warfarin due to potential decreased anticoagulant effect.
- Inform patients that CoQ10 is a supplement and not a replacement for prescribed cardiac medications.
Patient Guidelines
- Take the tablet with food, preferably a fatty meal, for better absorption.
- Do not exceed the recommended dose without consulting your doctor.
- Inform your doctor or pharmacist about all other medications and supplements you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Dopair 100 mg tablet generally does not affect driving ability or the operation of machinery. However, if you experience dizziness or headache, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet and engage in regular exercise for overall well-being.
- Remember that CoQ10 is a supplement and not a substitute for prescribed medication or a healthy lifestyle.
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