Doquin
Generic Name
Doxycycline
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| doquin 500 mg tablet | ৳ 12.09 | N/A |
Description
Overview of the medicine
Doquin 500 mg Tablet is a broad-spectrum antibiotic from the tetracycline class, containing Doxycycline. It is used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
The standard dosage of Doxycycline is typically 100 mg to 200 mg per day. A 500 mg tablet is an unusually high strength and should only be used as directed by a physician for specific severe infections or specific loading dose regimens. Example: One tablet (500 mg) as a single dose for certain conditions or as part of a multi-day regimen for severe indications, strictly under medical supervision.
Elderly
No specific dose adjustment is generally required for elderly patients with normal renal and hepatic function. However, caution is advised, and dosage should be determined by the physician.
Renal_impairment
Doxycycline does not require significant dose adjustment in patients with renal impairment, as it is primarily excreted non-renally. However, close monitoring is recommended.
How to Take
Take the tablet orally with a full glass of water, preferably with food or milk to minimize gastric irritation. Do not lie down for at least 30 minutes (preferably 1 hour) after taking the medication to prevent esophageal irritation or ulceration. Complete the full prescribed course of treatment.
Mechanism of Action
Doxycycline works by inhibiting bacterial protein synthesis. It reversibly binds to the 30S ribosomal subunit of susceptible bacteria, thereby preventing the attachment of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. This action stops bacterial growth and replication.
Pharmacokinetics
Onset
The antibacterial effects begin shortly after absorption, but clinical resolution of infection depends on the pathogen and severity. Full therapeutic effect may take several days.
Excretion
Doxycycline is primarily excreted via feces (bile and intestine) and, to a lesser extent, via urine (renal excretion). Renal impairment has minimal effect on its half-life, making it safer for use in kidney disease than other tetracyclines.
Half life
The plasma elimination half-life of doxycycline is approximately 16 to 24 hours in individuals with normal renal function.
Absorption
Doxycycline is well and rapidly absorbed from the gastrointestinal tract after oral administration, with bioavailability typically around 90-100%. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Doxycycline is only partially metabolized in the liver, primarily by glucuronidation. A significant portion is excreted in its active form.
Side Effects
Contraindications
- Hypersensitivity to doxycycline or any other tetracycline antibiotic
- Children under 8 years of age (due to risk of permanent tooth discoloration and bone growth inhibition)
- Pregnancy (especially in the second and third trimesters, due to effects on fetal bone and tooth development)
- Severe hepatic impairment
Drug Interactions
Penicillin
Doxycycline is bacteriostatic and may interfere with the bactericidal action of penicillin. Avoid concomitant use.
Oral contraceptives
May reduce the efficacy of oral contraceptives. Advise patients to use additional non-hormonal contraception.
Warfarin (anticoagulants)
Doxycycline may potentiate the anticoagulant effect of warfarin. Increased monitoring of INR is recommended.
Barbiturates, carbamazepine, phenytoin
These drugs can induce hepatic enzymes, leading to decreased doxycycline half-life and therapeutic effect.
Iron preparations and zinc supplements
Can decrease doxycycline absorption. Separate administration by at least 2-3 hours.
Antacids containing aluminum, calcium, or magnesium
May significantly reduce the absorption of doxycycline. Administer doxycycline 2-3 hours before or after antacids.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be considered if ingestion is recent. Treatment is primarily symptomatic and supportive. Fluid and electrolyte balance should be maintained. Hemodialysis or peritoneal dialysis is not effective in removing doxycycline from the body.
Pregnancy & Lactation
Doxycycline is categorized as Pregnancy Category D. It should not be used during pregnancy, especially in the second and third trimesters, due to the risk of permanent tooth discoloration and skeletal effects in the developing fetus. Doxycycline is excreted into breast milk and is contraindicated during lactation due to potential adverse effects on the nursing infant, including tooth discoloration and inhibition of bone growth. Alternatives should be considered.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture when stored under recommended conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved for various bacterial infections
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Doxycycline has undergone extensive clinical trials supporting its efficacy and safety across various bacterial infections since its introduction. Ongoing research continues to explore its use in new indications and resistant strains.
Lab Monitoring
- For long-term therapy, periodic laboratory evaluation of organ systems, including hematopoietic, renal, and hepatic studies, is recommended.
- Monitoring of liver function tests may be considered in patients with pre-existing hepatic impairment or during prolonged treatment.
Doctor Notes
- Emphasize patient education regarding proper administration (with water, upright position) to minimize esophageal irritation.
- Counsel patients on photosensitivity precautions (sunscreen, protective clothing, avoiding peak sun hours).
- Advise female patients on hormonal contraception about potential reduced efficacy and the need for backup contraception.
- Confirm patient age, especially avoiding use in children under 8 years unless absolutely necessary.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop taking it prematurely, even if you feel better.
- Drink a full glass of water with each dose and remain upright for at least 30 minutes after taking to prevent esophageal irritation.
- Avoid direct sunlight and use sunscreen/protective clothing, as doxycycline can cause photosensitivity.
- Avoid dairy products, antacids, and iron supplements for at least 2-3 hours before or after taking Doquin 500 mg tablet.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Doxycycline may cause dizziness or visual disturbances in some patients. If you experience these symptoms, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids throughout the day.
- Protect your skin from sun exposure to minimize the risk of photosensitivity reactions.
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Global Brand Names
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