Dorakid
Generic Name
Ibuprofen + Paracetamol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Dorakid is a combination medicine containing Ibuprofen and Paracetamol, used to relieve fever, pain, and inflammation in children. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and Paracetamol is an analgesic and antipyretic. This combination provides synergistic action for better symptom relief.
Uses & Indications
Dosage
Adults
Not typically recommended for adults in this pediatric formulation. Refer to adult formulations of Ibuprofen + Paracetamol if needed.
Elderly
Not directly applicable for pediatric formulation. Elderly patients using adult formulations should use with caution due to increased risk of side effects, especially GI and renal.
Children
Based on age and weight, typically 10 mg/kg Ibuprofen and 15 mg/kg Paracetamol every 6-8 hours, not exceeding 4 doses in 24 hours. For specific strengths, follow physician's advice or package leaflet.
Renal_impairment
Use with caution. Dosage reduction may be necessary in severe renal impairment, particularly with Ibuprofen.
How to Take
Administer orally with or after food, using the provided measuring spoon or syringe. Shake the bottle well before each use.
Mechanism of Action
Ibuprofen inhibits prostaglandin synthesis by reversibly inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing pain, fever, and inflammation. Paracetamol's exact mechanism is not fully understood, but it is believed to inhibit prostaglandin synthesis primarily in the central nervous system, producing analgesic and antipyretic effects.
Pharmacokinetics
Onset
Analgesic and antipyretic effects usually begin within 30-60 minutes.
Excretion
Both drugs and their metabolites are primarily excreted by the kidneys in the urine. A small amount of Ibuprofen is excreted in bile.
Half life
Ibuprofen has a plasma half-life of approximately 1.8-3.5 hours. Paracetamol has a plasma half-life of 1.5-4 hours.
Absorption
Both Ibuprofen and Paracetamol are rapidly and well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations of Ibuprofen are usually reached within 1-2 hours and Paracetamol within 30-60 minutes.
Metabolism
Ibuprofen is extensively metabolized in the liver via oxidation and glucuronidation. Paracetamol is primarily metabolized in the liver by glucuronidation and sulfation, with a small amount by CYP2E1 to a toxic intermediate (NAPQI) which is detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to Ibuprofen, Paracetamol, or any component of the formulation
- Active peptic ulcer or gastrointestinal bleeding
- Severe hepatic or renal impairment
- Aspirin-sensitive asthma or other NSAID-induced allergic reactions
- Congestive heart failure (NYHA Class II-IV)
- Third trimester of pregnancy
Drug Interactions
Alcohol
Increased risk of liver damage with Paracetamol, increased GI bleeding risk with Ibuprofen.
Lithium
Ibuprofen can increase lithium plasma levels.
Warfarin
Increased risk of bleeding with Ibuprofen.
Methotrexate
Ibuprofen can increase methotrexate levels and toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal side effects.
ACE Inhibitors / Diuretics
Reduced antihypertensive and diuretic effects, increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep tightly closed.
Overdose
Overdose symptoms may include nausea, vomiting, abdominal pain, drowsiness, and headache for Ibuprofen, and severe liver damage, nausea, vomiting, and abdominal pain for Paracetamol. Management involves immediate gastric lavage or activated charcoal administration. For Paracetamol overdose, N-acetylcysteine should be administered promptly. For Ibuprofen, supportive care and symptomatic treatment are key.
Pregnancy & Lactation
Ibuprofen is contraindicated in the third trimester of pregnancy due to risks to the fetus. Paracetamol is generally considered safe during pregnancy. Due to the Ibuprofen component, this combination should be avoided during late pregnancy. Both drugs are excreted in breast milk in small amounts; use with caution during lactation and consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date (unopened). Once opened, use within 28 days.
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of both Ibuprofen and Paracetamol individually and in combination for various pain and fever conditions, particularly in pediatric populations. Studies have shown the combination can provide faster and more complete relief than monotherapy.
Lab Monitoring
- For long-term use: Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
Doctor Notes
- Educate parents/guardians on proper dosing based on child's weight/age to avoid overdose, especially with combination products.
- Advise caution in patients with a history of asthma, allergies, GI issues, or renal/hepatic impairment.
- Emphasize short-term use and prompt consultation if symptoms persist or new symptoms appear.
Patient Guidelines
- Do not exceed the recommended dose or duration of treatment.
- Always use the provided measuring device for accurate dosing.
- Consult a doctor if symptoms persist for more than 3 days (fever) or 5 days (pain) or worsen.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to compensate for a missed one.
Driving Precautions
Not directly relevant for the primary pediatric target. For older children/adults, if dizziness or drowsiness occurs, caution should be exercised when driving or operating machinery.
Lifestyle Advice
- Ensure adequate hydration, especially when fever is present.
- Encourage rest to aid recovery.
- For adults using similar formulations, avoid alcohol consumption due to increased risk of side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.