Doribac
Generic Name
Doripenem
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| doribac 500 mg capsule | ৳ 10.53 | ৳ 42.12 |
Description
Overview of the medicine
Doribac 500 mg Capsule is a broad-spectrum antibiotic belonging to the carbapenem class, used to treat various severe bacterial infections. It is effective against both Gram-positive and Gram-negative bacteria, including many resistant strains.
Uses & Indications
Dosage
Adults
500 mg orally every 8 hours, for 5 to 14 days, depending on the infection severity and type. Dosage should be adjusted based on clinical response and microbiological results.
Elderly
No specific dosage adjustment is required for elderly patients with normal renal function. For elderly patients with renal impairment, dosage adjustment as per renal impairment guidelines is necessary.
Renal_impairment
For creatinine clearance (CrCl) 30 to 50 mL/min: 250 mg every 8 hours. For CrCl 10 to <30 mL/min: 250 mg every 12 hours. For CrCl <10 mL/min or hemodialysis: 250 mg every 24 hours (after dialysis on dialysis days).
How to Take
Take the capsule orally, with or without food. Swallow the capsule whole with a glass of water. Do not crush, chew, or open the capsule.
Mechanism of Action
Doripenem, the active ingredient in Doribac, works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which are essential for peptidoglycan synthesis, thereby leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Therapeutic concentrations typically achieved within 1-2 hours after administration.
Excretion
Primarily excreted unchanged in the urine (around 70% of the dose) via glomerular filtration and tubular secretion. Remaining portion excreted via non-renal routes.
Half life
Approximately 2-3 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract following oral administration. Bioavailability is high.
Metabolism
Minimal hepatic metabolism; primarily metabolized by dehydropeptidase-I (DHP-I) in the kidneys, but Doripenem is relatively stable to DHP-I.
Side Effects
Contraindications
- Known hypersensitivity to Doripenem, other carbapenems, or any component of the formulation.
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agent (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Probenecid competes with Doripenem for active tubular secretion, resulting in increased plasma concentrations and prolonged half-life of Doripenem. Co-administration is generally not recommended.
Oral Anticoagulants
Monitoring of INR is recommended during co-administration with warfarin as changes in anticoagulant effects have been reported with other beta-lactam antibiotics.
Valproic Acid/Divaproex
Carbapenems, including Doripenem, may decrease serum valproic acid concentrations to subtherapeutic levels, increasing the risk of seizures. Co-administration is generally not recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. Doripenem can be removed by hemodialysis. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Doripenem is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by national regulatory authorities
Patent Status
Patent expired; generic versions available
Clinical Trials
Extensive clinical trials have established Doripenem's efficacy and safety for its approved indications. Ongoing research explores its potential in new indications and in combating antimicrobial resistance.
Lab Monitoring
- Regular monitoring of renal function (creatinine clearance, serum creatinine) in patients with impaired renal function.
- Periodic monitoring of liver function tests (LFTs) for patients on prolonged therapy.
- Monitoring of complete blood count (CBC) during extended treatment courses.
Doctor Notes
- Perform susceptibility testing to confirm appropriate Doripenem therapy, especially for severe infections or resistant pathogens.
- Monitor for signs of hypersensitivity reactions, C. difficile infection, and neurological events (e.g., seizures).
- Adjust dosage carefully in patients with renal impairment.
Patient Guidelines
- Complete the entire prescribed course of Doribac, even if symptoms improve, to prevent the development of antibiotic resistance.
- Do not share this medication with others, as it may not be suitable for their condition.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Doribac may cause dizziness or seizures in some patients, which could impair the ability to drive or operate machinery. Patients should be advised to observe how they react to the medication before engaging in such activities.
Lifestyle Advice
- Maintain good personal hygiene to help prevent infections.
- Stay hydrated by drinking plenty of fluids during treatment.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.