Doriject
Generic Name
Doripenem
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| doriject 500 mg injection | ৳ 2,000.00 | N/A |
Description
Overview of the medicine
Doriject (Doripenem) is a broad-spectrum carbapenem antibiotic used to treat serious bacterial infections, including complicated intra-abdominal infections, complicated urinary tract infections, and pneumonia.
Uses & Indications
Dosage
Adults
500 mg administered by intravenous infusion over 1 hour every 8 hours. Duration of treatment varies based on infection type and severity (e.g., 5-14 days).
Elderly
No specific dose adjustment is needed based on age alone, but renal function should be considered.
Renal_impairment
Dose adjustment required for patients with creatinine clearance ≤ 50 mL/min (e.g., 250 mg every 8 or 12 hours).
How to Take
Administer intravenously via infusion over 1 hour. Do not administer as a bolus injection.
Mechanism of Action
Doripenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid onset of action due to IV administration.
Excretion
Primarily excreted unchanged in the urine (around 70% within 24 hours).
Half life
Approximately 1 hour.
Absorption
Rapidly absorbed after intravenous administration. Bioavailability is 100%.
Metabolism
Minimally metabolized; primarily hydrolyzed to an inactive metabolite.
Side Effects
Contraindications
- Known hypersensitivity to doripenem or other carbapenem antibiotics
- Hypersensitivity to other beta-lactam antibiotics (e.g., penicillins, cephalosporins) due to potential cross-reactivity
Drug Interactions
Probenecid
Concomitant use of probenecid with doripenem is not recommended as it inhibits the renal tubular secretion of doripenem, increasing its plasma concentration and half-life.
Valproic acid
Concomitant use with carbapenems, including doripenem, may decrease valproic acid plasma concentrations to subtherapeutic levels. Monitor valproic acid levels and consider alternative anticonvulsant therapy.
Storage
Store dry powder at 20-25°C (68-77°F). Protect from light. Reconstituted solution should be used immediately or stored for a limited time under specific conditions.
Overdose
In the event of an overdose, discontinue doripenem and institute general supportive treatment. Hemodialysis may be useful in enhancing the elimination of doripenem from the body.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Doripenem is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to doripenem or other carbapenem antibiotics
- Hypersensitivity to other beta-lactam antibiotics (e.g., penicillins, cephalosporins) due to potential cross-reactivity
Drug Interactions
Probenecid
Concomitant use of probenecid with doripenem is not recommended as it inhibits the renal tubular secretion of doripenem, increasing its plasma concentration and half-life.
Valproic acid
Concomitant use with carbapenems, including doripenem, may decrease valproic acid plasma concentrations to subtherapeutic levels. Monitor valproic acid levels and consider alternative anticonvulsant therapy.
Storage
Store dry powder at 20-25°C (68-77°F). Protect from light. Reconstituted solution should be used immediately or stored for a limited time under specific conditions.
Overdose
In the event of an overdose, discontinue doripenem and institute general supportive treatment. Hemodialysis may be useful in enhancing the elimination of doripenem from the body.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Doripenem is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacture date.
Availability
Available in hospitals and pharmacies with prescription
Approval Status
Approved (FDA, DGDA)
Patent Status
Generic versions available, original patent expired
Clinical Trials
Extensive clinical trials have demonstrated doripenem's efficacy and safety in various severe bacterial infections, supporting its use as a carbapenem antibiotic.
Lab Monitoring
- Monitor renal function (creatinine, BUN)
- Monitor liver function tests (ALT, AST)
- Monitor complete blood count (CBC) during prolonged therapy
Doctor Notes
- Culture and susceptibility testing should be performed to guide therapy. Empiric therapy with doripenem should be reviewed and adjusted if necessary.
- Monitor for signs of hypersensitivity reactions, especially in patients with a history of allergy to other beta-lactam antibiotics.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if you feel better.
- Report any severe or persistent side effects to your doctor immediately.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or seizures in some patients, which could impair the ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Maintain good hydration during treatment.
- Practice good hygiene to prevent further infections.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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