Dormir
Generic Name
Zolpidem Tartrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dormir 05 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Dormir 5 mg tablet contains Zolpidem tartrate, a non-benzodiazepine hypnotic used for the short-term treatment of insomnia characterized by difficulties with sleep initiation.
Uses & Indications
Dosage
Adults
Initial dose 5 mg taken orally once daily immediately before bedtime. Max 10 mg/day. Should not exceed 10 mg/day. Use for short periods, usually 7-10 days.
Elderly
Initial dose 5 mg orally once daily immediately before bedtime. Due to increased sensitivity and risk of adverse effects, a 5 mg dose is recommended.
Renal_impairment
No dose adjustment generally necessary for mild to moderate renal impairment, but caution is advised. For severe impairment, consultation with physician is recommended.
How to Take
Take orally immediately before bedtime. Do not take with or immediately after a meal as this may delay onset of action. Swallow whole, do not crush or chew.
Mechanism of Action
Zolpidem selectively binds to the omega-1 receptor subtype of the GABA-A receptor complex, enhancing GABAergic inhibition, leading to sedative, hypnotic, anxiolytic, and anticonvulsant effects.
Pharmacokinetics
Onset
Typically within 30 minutes.
Excretion
Metabolites are primarily excreted in urine (about 48-67%) and feces (about 29-39%).
Half life
Approximately 2.5-3 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached in 0.5-3 hours.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 enzymes, forming inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to zolpidem or any component of the formulation.
- Severe hepatic impairment.
- Sleep apnea syndrome.
- Myasthenia gravis.
- Severe respiratory insufficiency.
Drug Interactions
Alcohol
Increases CNS depressant effects.
CYP3A4 inducers (e.g., rifampicin, carbamazepine)
May decrease zolpidem plasma levels, reducing efficacy.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May increase zolpidem plasma levels, increasing risk of side effects.
Other CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants)
Potentiates CNS depressant effects, increasing risk of respiratory depression and sedation.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include impaired consciousness ranging from somnolence to coma, and cardiorespiratory depression. Treatment is supportive; gastric lavage if recent ingestion, activated charcoal. Flumazenil may be considered but is rarely indicated.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Not recommended during lactation as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years from manufacturing date.
Availability
Pharmacies
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety for short-term insomnia treatment. Ongoing post-market surveillance monitors long-term effects and rare adverse events.
Lab Monitoring
- No specific routine lab monitoring required.
- Monitor liver function in patients with hepatic impairment.
Doctor Notes
- Emphasize short-term use (typically <4 weeks).
- Assess for underlying causes of insomnia.
- Counsel patients on potential for complex sleep behaviors and dependence.
- Start with the lowest effective dose, especially in elderly patients.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not take more than the recommended dose.
- Take immediately before going to bed, and only if you can get a full 7-8 hours of sleep.
- Avoid alcohol while taking this medicine.
- Do not drive or operate machinery after taking this medicine.
Missed Dose Advice
If a dose is missed, do not take it unless you have at least 7-8 hours available for sleep. Do not double the dose.
Driving Precautions
Dormir can cause drowsiness, dizziness, and impaired coordination. Do not drive or operate heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Practice good sleep hygiene (e.g., consistent bedtime, quiet environment, avoiding caffeine before sleep).
- Address underlying causes of insomnia.
- Avoid long-term use; use for the shortest duration necessary.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.