Take orally with a full glass of water. It is best taken with food to minimize gastric irritation, but avoid dairy products, calcium supplements, iron preparations, and antacids within 2 hours of taking Dos. Remain upright for at least 30 minutes after taking the medicine to prevent esophageal irritation.

Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the attachment of aminoacyl-tRNA to the ribosomal A site. This leads to the inhibition of bacterial growth and replication (bacteriostatic effect).

• •Hypersensitivity to doxycycline or other tetracyclines
• •Children under 8 years of age (due to risk of permanent tooth discoloration)
• •Pregnancy and lactation

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose may include severe nausea, vomiting, and diarrhea. Management is primarily symptomatic and supportive, including gastric lavage and appropriate fluid and electrolyte replacement. Hemodialysis is not effective in removing doxycycline.

Pregnancy Category D. Doxycycline crosses the placenta and can cause permanent tooth discoloration and skeletal abnormalities in the fetus. Generally contraindicated in pregnant and lactating women. Consult a doctor.