Doxyn
Generic Name
dos
Manufacturer
MediPharma Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Dos (doxycycline) is a broad-spectrum tetracycline antibiotic used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and certain sexually transmitted infections. It is also used for malaria prophylaxis and severe acne.
Uses & Indications
Dosage
Adults
Standard dose is 100 mg orally once or twice daily, depending on the infection. For severe infections, 100 mg every 12 hours.
Elderly
No specific dose adjustment is generally required, but caution is advised due to potential comorbidities.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment, as doxycycline is primarily excreted non-renally.
How to Take
Take orally with a full glass of water. It is best taken with food to minimize gastric irritation, but avoid dairy products, calcium supplements, iron preparations, and antacids within 2 hours of taking Dos. Remain upright for at least 30 minutes after taking the medicine to prevent esophageal irritation.
Mechanism of Action
Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the attachment of aminoacyl-tRNA to the ribosomal A site. This leads to the inhibition of bacterial growth and replication (bacteriostatic effect).
Pharmacokinetics
Onset
Within 1-2 hours of administration.
Excretion
Excreted mainly unchanged in feces (via bile) and urine.
Half life
16-24 hours.
Absorption
Well absorbed after oral administration, approximately 90-100% absorption. Absorption is slightly reduced by food and dairy products.
Metabolism
Minimally metabolized; primarily inactivated by chelation.
Side Effects
Contraindications
- Hypersensitivity to doxycycline or other tetracyclines
- Children under 8 years of age (due to risk of permanent tooth discoloration)
- Pregnancy and lactation
Drug Interactions
Penicillins
Tetracyclines may interfere with the bactericidal action of penicillins.
Methotrexate
Increased risk of methotrexate toxicity.
Oral contraceptives
May reduce efficacy of oral contraceptives.
Anticoagulants (e.g., Warfarin)
May potentiate anticoagulant effects, requiring dose adjustment.
Antacids, iron preparations, calcium supplements
Decreased absorption of doxycycline. Administer 2 hours apart.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, and diarrhea. Management is primarily symptomatic and supportive, including gastric lavage and appropriate fluid and electrolyte replacement. Hemodialysis is not effective in removing doxycycline.
Pregnancy & Lactation
Pregnancy Category D. Doxycycline crosses the placenta and can cause permanent tooth discoloration and skeletal abnormalities in the fetus. Generally contraindicated in pregnant and lactating women. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Doxycycline has undergone extensive clinical trials and continues to be studied for new indications and resistance patterns.
Lab Monitoring
- Liver function tests (with prolonged use)
- Kidney function tests (with prolonged use)
- Complete blood count (CBC)
Doctor Notes
- Counsel patients on photosensitivity and the importance of sun protection.
- Advise patients about esophageal irritation and proper administration with water and remaining upright.
- Emphasize completing the full course of therapy to prevent antibiotic resistance.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if your symptoms improve.
- Avoid direct sunlight and use protective clothing/sunscreen due to photosensitivity.
- Take with plenty of water and remain upright for at least 30 minutes to prevent esophageal irritation.
- Do not take with dairy products, antacids, or iron supplements. Maintain a 2-hour gap.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Dos (doxycycline) may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Practice safe sex to prevent sexually transmitted infections.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.