Medicine Information

Doxcline

Name: Doxcline
Brand: Doxcline
Rating: 4.5 (117 reviews)

Capsule100 mgTetracycline AntibioticsATC: J01AA02

Generic Name

Doxycycline Hyclate 100 mg Capsule

Manufacturer

Various Manufacturers

Country

Global; often manufactured in countries like India, Bangladesh, USA, Europe

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
doxcline 100 mg capsule	৳ 2.01	৳ 20.10

Description

Overview of the medicine

Doxycycline is a broad-spectrum tetracycline antibiotic used to treat various bacterial infections, malaria prophylaxis, and certain sexually transmitted infections. It works by inhibiting bacterial protein synthesis.

Uses & Indications

Bacterial infections (respiratory tract, urinary tract, skin, soft tissue)

Acne vulgaris

Malaria prophylaxis and treatment

Lyme disease

Chlamydia and Gonorrhea

Cholera

Dosage

Adults

Typical adult dosage is 100 mg orally once or twice daily depending on the infection. For severe infections, 100 mg every 12 hours. For malaria prophylaxis: 100 mg once daily.

Elderly

No specific dosage adjustment needed for elderly unless severe hepatic impairment.

Renal_impairment

No dosage adjustment necessary for renal impairment, as it is primarily excreted non-renally.

How to Take

Take capsules orally with a full glass of water, preferably while sitting or standing, to reduce the risk of esophageal irritation. Can be taken with food (but not dairy) to minimize gastric upset.

Mechanism of Action

Doxycycline inhibits bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit, thereby preventing the attachment of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex.

Pharmacokinetics

Onset

Antibacterial effects usually within 24-48 hours.

Excretion

Primarily excreted unchanged in faeces via intestinal secretion (non-biliary) and to a lesser extent in urine.

Half life

16-22 hours (can be longer in renal impairment).

Absorption

Well absorbed orally (approx. 90-100%), even with food, though dairy products and antacids can reduce absorption.

Metabolism

Minimally metabolized; primarily inactivated by chelate formation in the gut.

Side Effects

Contraindications

Hypersensitivity to doxycycline or other tetracyclines
Pregnancy (especially second/third trimester)
Children under 8 years of age (due to potential for tooth discoloration and bone growth inhibition)
Severe hepatic impairment

Drug Interactions

Warfarin

May enhance anticoagulant effect; monitor INR.

Penicillins

May interfere with the bactericidal action of penicillins; avoid co-administration.

Oral contraceptives

May reduce efficacy of hormonal contraceptives; advise backup birth control.

Barbiturates, carbamazepine, phenytoin

Can decrease doxycycline half-life through enzyme induction.

Antacids, iron supplements, calcium supplements, bismuth subsalicylate

Can decrease doxycycline absorption. Separate administration by at least 2-3 hours.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms include nausea, vomiting, diarrhea, and potentially liver toxicity. Treatment is supportive; gastric lavage or induction of emesis may be considered soon after ingestion. Hemodialysis is not effective.

Pregnancy & Lactation

Pregnancy Category D. Contraindicated during pregnancy (especially in the second and third trimesters) due to potential for permanent tooth discoloration and skeletal effects in the fetus. Not recommended during lactation as it is excreted in breast milk and may affect bone and tooth development in infants.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules (1x10)20 capsules (2x10)100 capsules (10x10)

Shelf Life

Typically 2-3 years from manufacturing date.

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)

Patent Status

Off-patent (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established doxycycline's efficacy for various bacterial infections, malaria prophylaxis, and dermatological conditions. Ongoing research continues to explore new uses and optimize regimens.

Lab Monitoring

Liver function tests (for prolonged therapy or pre-existing hepatic impairment)
Kidney function tests (not usually required but consider in severe cases)
Complete blood count (for prolonged therapy)

Doctor Notes

Emphasize proper administration (with water, upright) to patients.
Counsel on photosensitivity and the use of sunscreen.
Advise patients to report severe diarrhea (indicating C. difficile) immediately.
Caution against use in pregnant women and young children.

Patient Guidelines

Take with plenty of water to prevent esophageal irritation.
Avoid lying down for at least 30 minutes to 1 hour after taking the dose.
Avoid sun exposure or use sunscreen due to photosensitivity.
Do not take with dairy products, antacids, or iron supplements.
Complete the full course of treatment even if symptoms improve.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses at once to make up for a missed dose.