Medicine Information

Drometa

Name: Drometa
Brand: Drometa
Rating: 4.5 (117 reviews)

Injection4 mgAntiemeticATC: A04AA01

Generic Name

Ondansetron

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
drometa 4 mg injection	৳ 5,000.00	N/A

Description

Overview of the medicine

Drometa 4 mg Injection contains Ondansetron, an antiemetic medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery.

Uses & Indications

Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.

Prevention of nausea and vomiting associated with radiotherapy.

Prevention and treatment of postoperative nausea and vomiting.

Dosage

Adults

Chemotherapy: 8 mg IV slowly over 15 minutes, or 32 mg IV infusion. Postoperative: 4 mg IV single dose.

Elderly

No general dose adjustment is required, but caution with severe hepatic impairment.

Renal_impairment

No dose adjustment is required for renal impairment.

How to Take

Drometa 4 mg Injection is administered intravenously (IV) or intramuscularly (IM), as directed by a healthcare professional. IV doses should be given slowly.

Mechanism of Action

Ondansetron selectively blocks 5-hydroxytryptamine3 (5-HT3) receptors, which are located both centrally in the chemoreceptor trigger zone (CTZ) and peripherally on vagal nerve terminals in the gastrointestinal tract. This action inhibits the initiation of the vomiting reflex.

Pharmacokinetics

Onset

Within 30 minutes for IV administration.

Excretion

Primarily via urine (metabolites), with a small portion excreted in feces.

Half life

Approximately 3-5 hours.

Absorption

Rapid and complete absorption after intravenous (IV) or intramuscular (IM) administration.

Metabolism

Extensively metabolized in the liver by cytochrome P450 enzymes (CYP1A2, CYP2D6, CYP3A4).

Side Effects

Contraindications

Hypersensitivity to ondansetron or any component of the formulation.
Concomitant use with apomorphine.

Drug Interactions

Tramadol

May reduce the analgesic effect of tramadol.

Apomorphine

Severe hypotension and loss of consciousness (contraindicated).

QT-prolonging drugs

Increased risk of QT prolongation and Torsade de Pointes.

Phenytoin, Carbamazepine, Rifampicin

May decrease ondansetron plasma concentrations.

Storage

Store below 30°C. Protect from light. Do not freeze.

Overdose

Symptoms of overdose include transient visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block and QT prolongation. Treatment should be symptomatic and supportive, with ECG monitoring.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed. Ondansetron is excreted in the milk of lactating animals; it is unknown whether it is excreted in human milk. Caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 ampoule (4 mg/2 ml)5 ampoules (4 mg/2 ml) per pack

Shelf Life

24 to 36 months from the date of manufacture, specific to product labeling.

Availability

Pharmacies, hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Ondansetron has undergone extensive clinical trials demonstrating its efficacy and safety in preventing and treating chemotherapy-induced nausea and vomiting, radiation-induced nausea and vomiting, and postoperative nausea and vomiting.

Lab Monitoring

Liver function tests (in patients with hepatic impairment).
ECG monitoring (in patients with cardiac risk factors, hypokalemia, hypomagnesemia, or concomitant use of QT-prolonging drugs).

Doctor Notes

Ensure proper hydration, especially in patients receiving emetogenic chemotherapy.
Monitor ECG in patients with underlying cardiac conditions or those taking other QT-prolonging medications.
Strictly contraindicated with apomorphine due to severe hypotensive risk.

Patient Guidelines

Inform your doctor if you have a history of heart problems, liver disease, or allergies.
Report any symptoms like chest pain, irregular heartbeat, or severe dizziness to your healthcare provider immediately.
Do not use this medicine with apomorphine.

Missed Dose Advice

This medication is usually given in a hospital or clinic setting. If you miss an appointment for your dose, contact your doctor or nurse immediately to reschedule.