Drota
Generic Name
Drotaverine Hydrochloride
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| drota 40 mg tablet | ৳ 1.76 | ৳ 17.60 |
Description
Overview of the medicine
Drotaverine is an antispasmodic medication used to relieve spasms of the smooth muscles of various organs, providing relief from pain caused by such spasms.
Uses & Indications
Dosage
Adults
The usual adult dose is 40-80 mg, 1-3 times daily, or as directed by physician.
Elderly
No specific dose adjustment required, but caution is advised in elderly patients, especially those with cardiovascular issues.
Renal_impairment
No specific dose adjustment required in mild to moderate renal impairment, but caution is advised in severe cases.
How to Take
To be taken orally with water, with or without food. The tablet should be swallowed whole.
Mechanism of Action
Drotaverine selectively inhibits phosphodiesterase-4 (PDE4) enzyme, leading to increased intracellular cAMP. This increase in cAMP relaxes smooth muscles by reducing intracellular calcium levels, thereby alleviating spasms and pain.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted as metabolites in urine (about 50%) and feces (about 30%).
Half life
Approximately 8-10 hours.
Absorption
Rapid and complete absorption after oral administration. Peak plasma concentration reached within 45-60 minutes.
Metabolism
Extensively metabolized in the liver via O-demethylation.
Side Effects
Contraindications
- Hypersensitivity to drotaverine or any excipients
- Severe hepatic, renal, or cardiac insufficiency
- Second or third degree AV block
- Hypotension
- Children below 6 years of age
Drug Interactions
Levodopa
May reduce the antiparkinsonian effect of levodopa due to its PDE4 inhibitory action. Concomitant administration may lead to rigidity and tremor.
Other antispasmodics
Concomitant use with other antimuscarinic antispasmodics may lead to an additive effect, increasing the risk of side effects. Should be avoided or monitored closely.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include cardiac arrhythmias and conduction disorders, severe hypotension. Treatment is symptomatic and supportive, including gastric lavage and monitoring of vital signs and cardiac function.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefit outweighs the potential risk. Not recommended during lactation without physician's advice as it is unknown if drotaverine is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the manufacturing date, as indicated on the packaging.
Availability
Pharmacies nationwide
Approval Status
Approved by health authorities (e.g., DGDA in Bangladesh)
Patent Status
Generic available
Clinical Trials
Drotaverine has been extensively studied for its spasmolytic effects in various smooth muscle conditions. Clinical trials have demonstrated its efficacy in reducing pain and spasms associated with conditions like irritable bowel syndrome, renal colic, and dysmenorrhea. Ongoing research focuses on its broader applications and safety profile.
Lab Monitoring
- No specific routine lab monitoring required for short-term use.
- Liver and kidney function tests may be considered in prolonged use or specific conditions for patients with pre-existing conditions.
Doctor Notes
- Advise patients on potential dizziness and emphasize avoiding driving or operating heavy machinery if affected.
- Review concomitant medications for potential interactions, especially with levodopa.
- Monitor for signs of hypotension, particularly in elderly patients or those with pre-existing cardiovascular conditions.
- Caution in patients with severe hepatic, renal, or cardiac insufficiency.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications, herbal supplements, or vitamins you are taking.
- Avoid alcohol consumption during treatment as it may exacerbate certain side effects.
- If symptoms persist or worsen, consult a doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Drotaverine may cause dizziness, vertigo, or drowsiness in some individuals. Patients should be warned not to drive or operate machinery if they experience these symptoms.
Lifestyle Advice
- Maintain a healthy and balanced diet to avoid constipation.
- Stay well-hydrated by drinking plenty of fluids.
- Manage stress, as it can contribute to spasmodic conditions.
- Engage in light physical activity if appropriate and tolerated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.