DSEC-MUPS
Generic Name
Esomeprazole Magnesium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dsec mups 30 mg tablet | ৳ 11.00 | ৳ 110.00 |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor that reduces acid secretion in the stomach. It is used to treat various acid-related conditions such as GERD, ulcers, and Zollinger-Ellison Syndrome.
Uses & Indications
Dosage
Adults
Typical dosage is 20-40 mg once daily. For GERD: 20-40 mg once daily for 4-8 weeks. For Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks, maintenance 20 mg once daily.
Elderly
No specific dosage adjustment usually needed, but monitor for renal/hepatic impairment.
Renal_impairment
No dose adjustment required for mild to moderate impairment. For severe impairment, caution is advised.
How to Take
Oral, usually taken 30-60 minutes before a meal. Swallow the tablet whole; do not crush, chew, or divide.
Mechanism of Action
Selectively inhibits the H+/K+-ATPase (proton pump) in gastric parietal cells, thereby blocking the final step of acid production.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly via urine (approx. 80%) and feces (approx. 20%).
Half life
Approximately 1.3 hours (plasma), but acid suppression effect lasts much longer.
Absorption
Rapidly absorbed, bioavailability is approximately 64% after the first dose and increases to 89% with repeated doses.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Prolonged half-life of diazepam.
Warfarin
Increased INR and risk of bleeding.
Tacrolimus
Increased tacrolimus levels.
Clopidogrel
Reduced antiplatelet effect.
Methotrexate
Increased methotrexate levels.
Atazanavir/Nelfinavir
Decreased antiretroviral levels, avoid concomitant use.
Storage
Store below 30°C, away from moisture and direct sunlight. Keep out of reach of children.
Overdose
Limited experience. Symptoms might include drowsiness, blurred vision, tachycardia, nausea, sweating. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the potential risk to the fetus. Esomeprazole is excreted in breast milk; use with caution in lactating mothers.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Prolonged half-life of diazepam.
Warfarin
Increased INR and risk of bleeding.
Tacrolimus
Increased tacrolimus levels.
Clopidogrel
Reduced antiplatelet effect.
Methotrexate
Increased methotrexate levels.
Atazanavir/Nelfinavir
Decreased antiretroviral levels, avoid concomitant use.
Storage
Store below 30°C, away from moisture and direct sunlight. Keep out of reach of children.
Overdose
Limited experience. Symptoms might include drowsiness, blurred vision, tachycardia, nausea, sweating. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the potential risk to the fetus. Esomeprazole is excreted in breast milk; use with caution in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
DGDA Approved (Bangladesh)
Patent Status
Patent expired, allowing generics
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Esomeprazole in the treatment of various acid-related disorders.
Lab Monitoring
- No routine lab monitoring required for most patients.
- May monitor serum magnesium levels with long-term use (≥3 months)
Doctor Notes
- Counsel patients on proper administration (before food, swallowed whole).
- Advise against crushing/chewing the MUPS tablet.
- Monitor for potential drug interactions, especially with clopidogrel and warfarin.
- For long-term use, consider magnesium supplementation and bone density monitoring.
Patient Guidelines
- Take this medicine 30-60 minutes before food for best results.
- Swallow the tablet whole; do not crush, chew, or open it.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally considered safe for driving. However, if you experience dizziness or visual disturbances, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as fatty, spicy, acidic foods, caffeine, and carbonated drinks.
- Avoid alcohol and smoking as they can worsen acid reflux.
- Elevate the head of your bed if you suffer from GERD.
- Eat smaller, more frequent meals instead of large ones.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.