Dudon
Generic Name
Dudonil
Manufacturer
PharmaCorp Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dudon 10 mg tablet | ৳ 4.00 | ৳ 56.00 |
Description
Overview of the medicine
Dudon 10 mg Tablet contains Dudonil, an advanced anxiolytic used for the short-term treatment of anxiety disorders and insomnia. It helps to calm the brain and nerves, providing relief from tension and promoting restful sleep.
Uses & Indications
Dosage
Adults
For anxiety: 5-10 mg orally 2-3 times daily, or as directed by physician. For insomnia: 10 mg at bedtime.
Elderly
Lower initial dose recommended, e.g., 2.5-5 mg daily, adjusted based on response and tolerability.
Renal_impairment
Dosage reduction may be necessary; consult physician. No specific guidelines, but caution advised.
How to Take
Take orally with or without food. Do not crush or chew the tablet. Swallow whole with water. Administer at night for insomnia.
Mechanism of Action
Dudonil selectively binds to GABA-A receptors, enhancing the inhibitory effects of GABA. This results in decreased neuronal excitability and a calming effect on the central nervous system.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Excreted mainly via urine as metabolites.
Half life
Approximately 10-12 hours
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP3A4, into inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to Dudonil or any excipients
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Sleep apnea syndrome
- Severe hepatic impairment
Drug Interactions
Alcohol
Enhances CNS depressant effects, increased risk of adverse reactions.
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Antihistamines (sedating)
Additive sedative effects.
Antidepressants (SSRIs, TCAs)
Potentiation of sedative effects, increased risk of CNS depression.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Treatment is supportive, focusing on maintaining airways, vital signs, and gastric lavage if ingested recently. Flumazenil may be considered in severe cases, but with caution due to seizure risk.
Pregnancy & Lactation
Pregnancy Category D. Dudonil may cause fetal harm when administered to pregnant women. Avoid during pregnancy. Excreted in breast milk, so not recommended during lactation due to potential for sedation in infants.
Side Effects
Contraindications
- Known hypersensitivity to Dudonil or any excipients
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Sleep apnea syndrome
- Severe hepatic impairment
Drug Interactions
Alcohol
Enhances CNS depressant effects, increased risk of adverse reactions.
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Antihistamines (sedating)
Additive sedative effects.
Antidepressants (SSRIs, TCAs)
Potentiation of sedative effects, increased risk of CNS depression.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Treatment is supportive, focusing on maintaining airways, vital signs, and gastric lavage if ingested recently. Flumazenil may be considered in severe cases, but with caution due to seizure risk.
Pregnancy & Lactation
Pregnancy Category D. Dudonil may cause fetal harm when administered to pregnant women. Avoid during pregnancy. Excreted in breast milk, so not recommended during lactation due to potential for sedation in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent Pending
Clinical Trials
Clinical trials demonstrated significant efficacy in reducing anxiety symptoms and improving sleep latency. Data from Phase III trials support its short-term use. Post-marketing surveillance continues to monitor long-term safety and efficacy.
Lab Monitoring
- Liver function tests (LFTs) periodically, especially during prolonged therapy or in patients with hepatic impairment.
- Renal function tests (RFTs) may be monitored for dose adjustment in patients with renal impairment.
Doctor Notes
- Prescribe for the shortest effective duration to minimize dependence risk.
- Assess patients for a history of substance abuse or psychiatric disorders.
- Educate patients about potential withdrawal symptoms and the importance of gradual tapering.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor, as withdrawal symptoms may occur.
- Avoid consuming alcohol or other CNS depressants while taking Dudonil.
- Do not drive or operate heavy machinery until you know how this medicine affects you.
- Report any unusual mood changes, agitation, or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to make up for a missed one. Consult your doctor if unsure.
Driving Precautions
Dudonil may cause drowsiness, dizziness, and impaired concentration. Patients should be warned against engaging in hazardous occupations requiring complete mental alertness, such as operating machinery or driving a motor vehicle, until they know how the drug affects them.
Lifestyle Advice
- Maintain a regular sleep schedule and practice good sleep hygiene.
- Incorporate relaxation techniques like meditation or yoga to manage stress.
- Avoid large meals, caffeine, and strenuous exercise close to bedtime.
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Global Brand Names
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