Dumax
Generic Name
Domperidone
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dumax 30 mg tablet | ৳ 30.00 | ৳ 120.00 |
Description
Overview of the medicine
Domperidone is a dopamine antagonist that helps relieve nausea, vomiting, and certain digestive issues by increasing gastrointestinal motility. This 30 mg tablet is typically used for sustained release or specific dosage regimens.
Uses & Indications
Dosage
Adults
Typically 30 mg once daily, preferably 15-30 minutes before a meal. For standard domperidone (10mg), the dose is 10-20 mg three times daily. Max 30 mg/day.
Elderly
Similar to adults, but use with caution due to potential for cardiac effects.
Renal_impairment
In severe renal impairment (creatinine clearance <30 ml/min), the frequency of dosing should be reduced to once or twice daily depending on severity (e.g., 10 mg once or twice daily).
How to Take
Take orally, preferably 15-30 minutes before meals. Do not crush or chew sustained-release tablets.
Mechanism of Action
It selectively blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) in the brain, reducing nausea and vomiting. Additionally, it acts as a prokinetic agent by enhancing gastrointestinal motility, increasing lower esophageal sphincter pressure, and accelerating gastric emptying.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Primarily via feces (66%) and urine (33%), mostly as metabolites.
Half life
7-9 hours (can be prolonged in severe renal impairment)
Absorption
Rapidly absorbed after oral administration; peak plasma levels in 30-60 minutes. Low absolute bioavailability (~15%) due to extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to domperidone or any component of the formulation
- Prolactin-releasing pituitary tumor (prolactinoma)
- Moderate to severe hepatic impairment
- Known existing prolongation of cardiac QT intervals or significant cardiac disease
- Concomitant use of potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- Gastrointestinal hemorrhage, mechanical obstruction, or perforation
Drug Interactions
Dopamine agonists (e.g., bromocriptine, cabergoline)
Domperidone may antagonize their effects.
Potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Increased plasma levels of domperidone, increasing the risk of QT prolongation. Concomitant use is contraindicated.
Drugs that prolong the QT interval (e.g., antiarrhythmics, antipsychotics)
Increased risk of cardiac arrhythmias. Concomitant use should be avoided.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, disorientation, and extrapyramidal reactions. Management is symptomatic and supportive, including gastric lavage and activated charcoal if appropriate. ECG monitoring is recommended.
Pregnancy & Lactation
Pregnancy Category C (US FDA). Use only if the potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to domperidone or any component of the formulation
- Prolactin-releasing pituitary tumor (prolactinoma)
- Moderate to severe hepatic impairment
- Known existing prolongation of cardiac QT intervals or significant cardiac disease
- Concomitant use of potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- Gastrointestinal hemorrhage, mechanical obstruction, or perforation
Drug Interactions
Dopamine agonists (e.g., bromocriptine, cabergoline)
Domperidone may antagonize their effects.
Potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Increased plasma levels of domperidone, increasing the risk of QT prolongation. Concomitant use is contraindicated.
Drugs that prolong the QT interval (e.g., antiarrhythmics, antipsychotics)
Increased risk of cardiac arrhythmias. Concomitant use should be avoided.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, disorientation, and extrapyramidal reactions. Management is symptomatic and supportive, including gastric lavage and activated charcoal if appropriate. ECG monitoring is recommended.
Pregnancy & Lactation
Pregnancy Category C (US FDA). Use only if the potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy of domperidone in treating nausea, vomiting, dyspepsia, and improving gastric motility. Ongoing research may explore specific formulations or long-term safety profiles.
Lab Monitoring
- No routine lab monitoring is generally required. However, prolactin levels may be monitored if symptoms of hyperprolactinemia occur.
- ECG monitoring for patients with cardiac risk factors or on higher doses.
Doctor Notes
- Assess patient's cardiac history, including family history of sudden cardiac death, and concomitant medications that may prolong the QT interval.
- Consider alternative treatments for patients with significant cardiovascular risk factors.
- Prescribe the lowest effective dose for the shortest duration necessary.
Patient Guidelines
- Take exactly as prescribed by your doctor, preferably before meals.
- Do not exceed the recommended dose, especially if you have heart conditions or are over 60 years old.
- Report any unusual side effects, especially palpitations or fainting, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness. Exercise caution when driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Eating smaller, more frequent meals can help manage digestive symptoms.
- Avoid fatty and spicy foods that can worsen dyspepsia.
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