Durazol
Generic Name
Azithromycin 200 mg/5 ml Oral Suspension
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| durazol 200 mg suspension | ৳ 15.00 | N/A |
Description
Overview of the medicine
Durazol 200 mg Suspension contains Azithromycin, a macrolide antibiotic, used to treat various bacterial infections like respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases.
Uses & Indications
Dosage
Adults
For certain STDs, 25 ml (1000 mg) as a single dose; for respiratory infections, 12.5 ml (500 mg) once daily for 3 days.
Elderly
No specific dose adjustment generally required, but caution in patients with hepatic impairment.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment (CrCl > 10 mL/min).
How to Take
Oral administration. Can be taken with or without food. Shake well before use. Use the provided measuring device.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing translocation of peptide chains.
Pharmacokinetics
Onset
Variable, typically within 2-3 hours.
Excretion
Primarily excreted unchanged in bile; a small portion is excreted via urine.
Half life
Approximately 2-4 days (tissue half-life).
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Antacids
Decreased peak plasma concentration of azithromycin.
Pimozide
Concomitant use contraindicated due to risk of QT prolongation.
Warfarin
Increased anticoagulant effect.
Nelfinavir
Increased azithromycin concentrations.
Storage
Store powder below 30°C. Do not freeze. Store reconstituted suspension below 30°C and discard after 10 days.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Antacids
Decreased peak plasma concentration of azithromycin.
Pimozide
Concomitant use contraindicated due to risk of QT prolongation.
Warfarin
Increased anticoagulant effect.
Nelfinavir
Increased azithromycin concentrations.
Storage
Store powder below 30°C. Do not freeze. Store reconstituted suspension below 30°C and discard after 10 days.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted powder); 10 days (reconstituted suspension, stored below 30°C).
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated azithromycin's efficacy and safety in various bacterial infections, including those in pediatric and adult populations.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment)
- Renal function tests (in severe renal impairment)
- ECG monitoring (in patients at risk for QT prolongation)
Doctor Notes
- Emphasize completing the full course of treatment to prevent antibiotic resistance.
- Counsel patients on potential QT prolongation risks, especially those with pre-existing cardiac conditions or on other QT-prolonging drugs.
- Advise on proper reconstitution and administration technique for suspensions, especially for pediatric patients.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Shake the suspension well before each use.
- Use the provided measuring device for accurate dosing.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances. Patients should be advised to exercise caution when driving or operating machinery until they are reasonably certain that azithromycin does not adversely affect their ability.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol during treatment if experiencing gastrointestinal upset.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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