Durevolis
Generic Name
Tadalafil
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| durevolis 20 mg tablet | ৳ 60.00 | ৳ 240.00 |
Description
Overview of the medicine
Durevolis 20 mg Tablet contains Tadalafil, a phosphodiesterase-5 (PDE5) inhibitor, used to treat erectile dysfunction (ED) and symptoms of benign prostatic hyperplasia (BPH).
Uses & Indications
Dosage
Adults
For ED: 10 mg or 20 mg taken prior to anticipated sexual activity. Max 1 dose/day. For BPH: 5 mg once daily. For ED/BPH: 5 mg once daily.
Elderly
No dose adjustment specifically for elderly based on age, but consider overall health and renal function.
Renal_impairment
Mild to moderate: No adjustment. Severe: Max 5 mg not more than once every 72 hours for ED. Not recommended for BPH.
How to Take
Orally, with or without food. For ED, take prior to sexual activity. For BPH, take once daily at approximately the same time.
Mechanism of Action
Tadalafil inhibits phosphodiesterase-5 (PDE5), an enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. By inhibiting PDE5, Tadalafil increases cGMP levels, leading to smooth muscle relaxation and increased blood flow into the penis, resulting in an erection. For BPH, it relaxes smooth muscle in the prostate and bladder.
Pharmacokinetics
Onset
Typically 30-60 minutes for ED, with effects lasting up to 36 hours.
Excretion
Mainly excreted in feces (approximately 61% of the dose) and to a lesser extent in urine (approximately 36% of the dose) as metabolites.
Half life
Approximately 17.5 hours (single dose in healthy subjects).
Absorption
Rapidly absorbed after oral administration, peak plasma concentration usually reached within 0.5 to 6 hours (median Tmax of 2 hours).
Metabolism
Primarily metabolized by cytochrome P450 3A4 (CYP3A4).
Side Effects
Contraindications
- •Concomitant use with nitrates (e.g., nitroglycerin), as it may potentiate hypotensive effects.
- •Hypersensitivity to Tadalafil or any component of the tablet.
- •Patients with heart problems for whom sexual activity is inadvisable.
- •Recent stroke or myocardial infarction (within 6 months).
- •Severe hepatic impairment.
- •Non-arteritic anterior ischemic optic neuropathy (NAION) history.
Drug Interactions
Nitrates
Potentiates hypotensive effects, potentially leading to life-threatening hypotension.
Riociguat
Contraindicated due to risk of severe hypotension.
Antihypertensives
May have additive blood pressure lowering effects.
CYP3A4 Inducers (e.g., Rifampicin)
Decreases Tadalafil exposure, potentially reducing efficacy.
Alpha-blockers (e.g., Tamsulosin, Doxazosin)
May cause symptomatic hypotension due to additive vasodilator effects.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
Increases Tadalafil exposure, potentially requiring dose reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, standard supportive measures should be adopted as necessary. Hemodialysis is not expected to accelerate clearance.
Pregnancy & Lactation
Tadalafil is not indicated for use in women. No data on use in pregnant or lactating women. Animal studies show no direct or indirect harmful effects with respect to reproductive toxicity.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired for Tadalafil)
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Global Brand Names
International brand names for this medicine
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