Dyana
Generic Name
Dienogest + Ethinylestradiol
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dyana 2 mg tablet | ৳ 210.00 | N/A |
Description
Overview of the medicine
Dyana is a combined oral contraceptive pill containing two active ingredients: dienogest (a progestogen) and ethinylestradiol (an estrogen). It is primarily used to prevent pregnancy. In some cases, it may also be used to treat moderate acne and excessive hair growth (hirsutism) in women who desire contraception.
Uses & Indications
Dosage
Adults
One tablet daily for 21 consecutive days, followed by a 7-day tablet-free interval. A new pack is started after the 7-day interval.
Elderly
Not indicated for postmenopausal women.
Renal_impairment
No specific dose adjustment required for mild to moderate renal impairment, but caution is advised. Not recommended for severe renal impairment.
How to Take
Take one tablet orally at approximately the same time each day. Tablets must be taken in the order directed on the blister pack.
Mechanism of Action
Dyana prevents pregnancy primarily by inhibiting ovulation (release of an egg from the ovary). It also causes changes in the cervical mucus, making it more difficult for sperm to reach the uterus, and alters the lining of the uterus, making it less receptive to implantation. The anti-androgenic effects of dienogest contribute to its use in treating acne and hirsutism.
Pharmacokinetics
Onset
Contraceptive effect usually starts after 7 consecutive days of active pill taking, provided it is started on the first day of menstruation.
Excretion
Metabolites of both components are primarily excreted via urine and bile. Dienogest is mainly excreted renally, while ethinylestradiol metabolites are excreted via urine and feces.
Half life
Ethinylestradiol: approximately 12-25 hours. Dienogest: approximately 9-10 hours.
Absorption
Both dienogest and ethinylestradiol are rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are reached within 1-2 hours for both components.
Metabolism
Both are extensively metabolized in the liver, primarily via hydroxylation and glucuronidation. Ethinylestradiol undergoes significant first-pass metabolism.
Side Effects
Contraindications
- •Presence or history of thrombosis (arterial or venous)
- •Severe liver disease
- •Undiagnosed vaginal bleeding
- •Known or suspected hormone-dependent malignancies (e.g., breast cancer)
- •Pancreatitis with severe hypertriglyceridaemia
- •Hypersensitivity to active substances or excipients
Drug Interactions
Herbal products (e.g., St. John's Wort)
May reduce contraceptive efficacy by inducing hepatic enzymes.
Antibiotics (e.g., rifampicin, griseofulvin)
May reduce contraceptive efficacy due to enzyme induction or alteration of gut flora.
Anticonvulsants (e.g., carbamazepine, phenytoin)
May decrease contraceptive efficacy by increasing hepatic metabolism of hormones.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, and withdrawal bleeding. No specific antidote; treatment is symptomatic and supportive.
Pregnancy & Lactation
Contraindicated during pregnancy. Not recommended during breastfeeding as it may reduce milk production and pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, clinics
Approval Status
Approved by major regulatory bodies for oral contraception
Patent Status
Patent expired for generic combination, brand patent may exist locally
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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