Dydrogest
Generic Name
Dydrogesterone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dydrogest 10 mg tablet | ৳ 40.00 | ৳ 400.00 |
Description
Overview of the medicine
Dydrogest 10 mg tablet contains Dydrogesterone, a synthetic progestogen that acts similarly to natural progesterone. It is used to treat a wide range of gynecological conditions caused by progesterone deficiency.
Uses & Indications
Dosage
Adults
Dosage varies widely based on indication. For example, for threatened miscarriage: 10 mg two to three times daily until symptoms subside. For endometriosis: 10 mg two to three times daily from day 5 to 25 of the cycle.
Elderly
No specific dosage adjustment is generally required for elderly patients, but caution is advised due to potential age-related organ function decline.
Renal_impairment
No specific studies have been conducted in patients with renal impairment. Caution is advised, and dosage adjustment might be necessary based on clinical judgment.
How to Take
Take orally with water, with or without food. It is recommended to take the tablets at regular intervals for optimal effect. Follow your doctor's instructions regarding timing and duration.
Mechanism of Action
Dydrogesterone is an orally active progestogen that selectively binds to progesterone receptors, mimicking the action of endogenous progesterone. It helps in regulating the menstrual cycle, supporting pregnancy, and alleviating symptoms of progesterone deficiency.
Pharmacokinetics
Onset
Onset of action varies depending on the indication.
Excretion
Excreted mainly via urine, primarily as glucuronic acid conjugates of DHD.
Half life
Dydrogesterone: 5-7 hours; main active metabolite (20α-dihydrodydrogesterone, DHD): 14-17 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 0.5-2.5 hours.
Metabolism
Extensively metabolized in the liver, primarily to 20α-dihydrodydrogesterone (DHD), which is also active.
Side Effects
Contraindications
- Known or suspected progestogen-dependent neoplasia (e.g., meningioma)
- Undiagnosed vaginal bleeding
- Hypersensitivity to the active substance or to any of the excipients
- History of idiopathic jaundice during pregnancy or severe pruritus
- Severe hepatic disease
Drug Interactions
Ritonavir, nelfinavir
May affect dydrogesterone metabolism.
Enzyme inducers (e.g., rifampicin, carbamazepine, phenobarbital, St. John's wort)
May decrease dydrogesterone levels, potentially reducing its efficacy.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach and sight of children.
Overdose
Dydrogesterone has low toxicity. Symptoms of overdose are generally mild and may include nausea, vomiting, dizziness, and somnolence. Treatment is symptomatic and supportive; no specific antidote is available.
Pregnancy & Lactation
Can be used in threatened or recurrent miscarriage under medical supervision, where the benefits outweigh the risks. Not recommended during breastfeeding as dydrogesterone is excreted in breast milk and potential effects on the infant are unknown.
Side Effects
Contraindications
- Known or suspected progestogen-dependent neoplasia (e.g., meningioma)
- Undiagnosed vaginal bleeding
- Hypersensitivity to the active substance or to any of the excipients
- History of idiopathic jaundice during pregnancy or severe pruritus
- Severe hepatic disease
Drug Interactions
Ritonavir, nelfinavir
May affect dydrogesterone metabolism.
Enzyme inducers (e.g., rifampicin, carbamazepine, phenobarbital, St. John's wort)
May decrease dydrogesterone levels, potentially reducing its efficacy.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach and sight of children.
Overdose
Dydrogesterone has low toxicity. Symptoms of overdose are generally mild and may include nausea, vomiting, dizziness, and somnolence. Treatment is symptomatic and supportive; no specific antidote is available.
Pregnancy & Lactation
Can be used in threatened or recurrent miscarriage under medical supervision, where the benefits outweigh the risks. Not recommended during breastfeeding as dydrogesterone is excreted in breast milk and potential effects on the infant are unknown.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, consult packaging for exact expiry.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Dydrogesterone has been extensively studied in numerous clinical trials for its approved indications, demonstrating efficacy and a favorable safety profile. Ongoing research continues to explore its full therapeutic potential.
Lab Monitoring
- No routine lab monitoring is generally required.
- Liver function tests may be considered periodically during prolonged use, especially in patients with a history of liver disease.
Doctor Notes
- Careful patient selection and accurate diagnosis of progesterone deficiency are crucial for effective treatment.
- Monitor patients for signs of venous thromboembolism (VTE) or arterial thromboembolism, although dydrogesterone is associated with a lower risk.
- For long-term use, especially in HRT, regular gynecological examinations and breast cancer screenings are recommended.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Dydrogest abruptly without consulting your doctor, especially if you are using it for miscarriage prevention.
- Report any unusual vaginal bleeding or persistent side effects to your doctor.
- If you are on hormone replacement therapy, ensure regular gynecological check-ups.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to compensate for a missed one.
Driving Precautions
Dydrogesterone may cause mild dizziness or somnolence in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how they react to the medication.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Engage in regular physical activity unless advised otherwise by your doctor.
- Avoid smoking and excessive alcohol consumption, as these can affect hormonal balance and overall health.
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