Dydrogest
Generic Name
Dydrogesterone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dydrogest 10 mg tablet | ৳ 40.00 | ৳ 400.00 |
Description
Overview of the medicine
Dydrogest 10 mg tablet contains Dydrogesterone, a synthetic progestogen that acts similarly to natural progesterone. It is used to treat a wide range of gynecological conditions caused by progesterone deficiency.
Uses & Indications
Dosage
Adults
Dosage varies widely based on indication. For example, for threatened miscarriage: 10 mg two to three times daily until symptoms subside. For endometriosis: 10 mg two to three times daily from day 5 to 25 of the cycle.
Elderly
No specific dosage adjustment is generally required for elderly patients, but caution is advised due to potential age-related organ function decline.
Renal_impairment
No specific studies have been conducted in patients with renal impairment. Caution is advised, and dosage adjustment might be necessary based on clinical judgment.
How to Take
Take orally with water, with or without food. It is recommended to take the tablets at regular intervals for optimal effect. Follow your doctor's instructions regarding timing and duration.
Mechanism of Action
Dydrogesterone is an orally active progestogen that selectively binds to progesterone receptors, mimicking the action of endogenous progesterone. It helps in regulating the menstrual cycle, supporting pregnancy, and alleviating symptoms of progesterone deficiency.
Pharmacokinetics
Onset
Onset of action varies depending on the indication.
Excretion
Excreted mainly via urine, primarily as glucuronic acid conjugates of DHD.
Half life
Dydrogesterone: 5-7 hours; main active metabolite (20α-dihydrodydrogesterone, DHD): 14-17 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 0.5-2.5 hours.
Metabolism
Extensively metabolized in the liver, primarily to 20α-dihydrodydrogesterone (DHD), which is also active.
Side Effects
Contraindications
- •Known or suspected progestogen-dependent neoplasia (e.g., meningioma)
- •Undiagnosed vaginal bleeding
- •Hypersensitivity to the active substance or to any of the excipients
- •History of idiopathic jaundice during pregnancy or severe pruritus
- •Severe hepatic disease
Drug Interactions
Ritonavir, nelfinavir
May affect dydrogesterone metabolism.
Enzyme inducers (e.g., rifampicin, carbamazepine, phenobarbital, St. John's wort)
May decrease dydrogesterone levels, potentially reducing its efficacy.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach and sight of children.
Overdose
Dydrogesterone has low toxicity. Symptoms of overdose are generally mild and may include nausea, vomiting, dizziness, and somnolence. Treatment is symptomatic and supportive; no specific antidote is available.
Pregnancy & Lactation
Can be used in threatened or recurrent miscarriage under medical supervision, where the benefits outweigh the risks. Not recommended during breastfeeding as dydrogesterone is excreted in breast milk and potential effects on the infant are unknown.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, consult packaging for exact expiry.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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