e-cof-plus
Generic Name
Guaifenesin 100 mg/5 ml + Dextromethorphan HBr 10 mg/5 ml + Phenylephrine HCl 5 mg/5 ml Syrup
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| e cof plus 100 mg syrup | ৳ 80.00 | N/A |
Description
Overview of the medicine
E-Cof Plus 100 mg Syrup is a combination medication used to relieve symptoms of cough, cold, and flu. It works by loosening mucus, suppressing cough, and clearing nasal congestion.
Uses & Indications
Dosage
Adults
10-20 ml (2-4 teaspoonfuls) every 4-6 hours, not exceeding 6 doses in 24 hours.
Elderly
No specific dose adjustment is usually required, but caution is advised due to potential increased sensitivity.
Renal_impairment
Use with caution; dose reduction may be necessary if severe impairment.
How to Take
Oral. Shake the bottle well before use. Use a measuring spoon/cup for accurate dosage.
Mechanism of Action
Guaifenesin works as an expectorant, reducing the viscosity of mucus in the airways, making it easier to cough up. Dextromethorphan HBr acts as an antitussive, suppressing the cough reflex by direct action on the cough center in the medulla. Phenylephrine HCl is a decongestant that stimulates alpha-adrenergic receptors in the respiratory tract, causing vasoconstriction and reduction of mucosal edema.
Pharmacokinetics
Onset
Onset of action typically within 15-30 minutes for decongestion and cough suppression, and expectorant effect within 30 minutes to an hour.
Excretion
Primarily excreted via the kidneys as metabolites and unchanged drug.
Half life
Guaifenesin: approx. 1 hour. Dextromethorphan: 1.4-3.9 hours. Phenylephrine: 2-3 hours.
Absorption
Guaifenesin is rapidly absorbed from the GI tract. Dextromethorphan is readily absorbed from the GI tract. Phenylephrine is well absorbed orally but undergoes significant first-pass metabolism.
Metabolism
Guaifenesin is metabolized via oxidation. Dextromethorphan is extensively metabolized in the liver by O-demethylation (CYP2D6). Phenylephrine is metabolized in the gut and liver by monoamine oxidase.
Side Effects
Contraindications
- Hypersensitivity to any component.
- Patients on MAO inhibitors or within 14 days of stopping them.
- Severe hypertension or coronary artery disease.
- Children under 2 years of age.
Drug Interactions
Beta-blockers
May potentiate the pressor effects of phenylephrine.
MAO Inhibitors
Concurrent use can lead to hypertensive crisis due to phenylephrine.
CNS Depressants (e.g., alcohol, sedatives)
May enhance CNS depression due to dextromethorphan.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dizziness, nausea, vomiting, agitation, hallucinations, high blood pressure, and seizures. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Consult a doctor before use. Generally considered category C. Use only if potential benefit outweighs risk.
Side Effects
Contraindications
- Hypersensitivity to any component.
- Patients on MAO inhibitors or within 14 days of stopping them.
- Severe hypertension or coronary artery disease.
- Children under 2 years of age.
Drug Interactions
Beta-blockers
May potentiate the pressor effects of phenylephrine.
MAO Inhibitors
Concurrent use can lead to hypertensive crisis due to phenylephrine.
CNS Depressants (e.g., alcohol, sedatives)
May enhance CNS depression due to dextromethorphan.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dizziness, nausea, vomiting, agitation, hallucinations, high blood pressure, and seizures. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Consult a doctor before use. Generally considered category C. Use only if potential benefit outweighs risk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical data available for individual active ingredients and common combinations demonstrating efficacy and safety for cough and cold symptoms.
Lab Monitoring
- Blood pressure monitoring (especially in patients with hypertension).
- No routine lab monitoring generally required.
Doctor Notes
- Advise patients on proper hydration and rest.
- Caution in patients with cardiac conditions, hypertension, hyperthyroidism, or prostate enlargement.
- Avoid co-administration with other sympathomimetics.
Patient Guidelines
- Do not exceed recommended dose.
- Consult a doctor if symptoms persist for more than 7 days.
- Do not use with other cough, cold, or flu medicines containing similar active ingredients.
- Avoid alcohol.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating machinery if affected.
Lifestyle Advice
- Drink plenty of fluids to help thin mucus.
- Get adequate rest.
- Maintain good hygiene to prevent spread of infection.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.