E-max-Mups
Generic Name
Esomeprazole (as magnesium) Delayed-Release Orally Disintegrating Tablet
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| e max mups 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
E-max-Mups 20 mg tablet contains esomeprazole, a proton pump inhibitor, used to reduce stomach acid production and treat conditions like GERD and ulcers.
Uses & Indications
Dosage
Adults
Typically 20-40 mg once daily. For GERD, 20-40 mg once daily for 4-8 weeks.
Elderly
No specific dose adjustment generally needed.
Renal_impairment
No dose adjustment needed.
How to Take
Orally, preferably 30-60 minutes before a meal. MUPS tablets can be dispersed in water or juice.
Mechanism of Action
Inhibits the H+/K+ ATPase (proton pump) in gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Primarily renal (approx. 80%) and fecal (approx. 20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration, bioavailability increases with repeated dosing.
Metabolism
Primarily hepatic via CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR/bleeding risk.
Clopidogrel
Reduced antiplatelet effect.
Methotrexate
Increased methotrexate levels.
Nelfinavir/Atazanavir
Reduced plasma levels.
Ketoconazole/Itraconazole
Reduced absorption (acid-dependent).
Storage
Store below 30°C in a dry place, protected from light and moisture.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if benefits outweigh risks. Exercise caution during lactation, consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR/bleeding risk.
Clopidogrel
Reduced antiplatelet effect.
Methotrexate
Increased methotrexate levels.
Nelfinavir/Atazanavir
Reduced plasma levels.
Ketoconazole/Itraconazole
Reduced absorption (acid-dependent).
Storage
Store below 30°C in a dry place, protected from light and moisture.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if benefits outweigh risks. Exercise caution during lactation, consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Generally approved worldwide
Patent Status
Off-patent (generic versions available)
WHO Essential Medicine
YesClinical Trials
Extensive trials have demonstrated the efficacy and safety of esomeprazole in various acid-related disorders, including GERD, peptic ulcers, and Zollinger-Ellison syndrome.
Lab Monitoring
- Long-term use (over 1 year): Monitor magnesium levels.
- Long-term use: Monitor vitamin B12 levels.
Doctor Notes
- Consider lowest effective dose for the shortest duration necessary.
- Periodically review the need for continued long-term PPI use.
- Be aware of potential drug interactions, especially with clopidogrel and warfarin.
Patient Guidelines
- Take the medicine consistently as prescribed by your doctor.
- Do not crush or chew the tablet (MUPS can be dispersed).
- Inform your doctor about any persistent side effects.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
Generally safe, but caution is advised if you experience dizziness or visual disturbances.
Lifestyle Advice
- Avoid trigger foods (spicy, fatty), alcohol, and smoking to help manage acid reflux symptoms.
- Maintain a healthy weight and elevate your head during sleep if you have GERD.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.