Ecofix
Generic Name
Ecometacin
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ec 6 mg tablet | ৳ 3.50 | ৳ 105.00 |
Description
Overview of the medicine
Ecometacin 6 mg tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, fever, and inflammation.
Uses & Indications
Dosage
Adults
The usual recommended dose is 6 mg to 12 mg every 4-6 hours as needed. Do not exceed 48 mg in 24 hours.
Elderly
Lower doses may be required, and patients should be monitored for adverse effects. Initial dose should be 6 mg every 6-8 hours.
Renal_impairment
Use with caution. Dosage reduction may be necessary in patients with moderate to severe renal impairment. Consult physician.
How to Take
Take the tablet orally, preferably with food or milk, to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water, do not chew or crush.
Mechanism of Action
Ecometacin exerts its anti-inflammatory, analgesic, and antipyretic effects by inhibiting prostaglandin synthesis through the reversible blockade of cyclooxygenase (COX-1 and COX-2) enzymes.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted in the urine as metabolites, with a small portion excreted in feces.
Half life
Approximately 2-4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver by oxidation and conjugation.
Side Effects
Contraindications
- Known hypersensitivity to Ecometacin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors (e.g., Lisinopril)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C. Avoid use during the third trimester of pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use only if clearly needed during first and second trimesters. It is not recommended during lactation as it may pass into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to Ecometacin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors (e.g., Lisinopril)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C. Avoid use during the third trimester of pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use only if clearly needed during first and second trimesters. It is not recommended during lactation as it may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired
Clinical Trials
Clinical trials for Ecometacin 6 mg have demonstrated efficacy in pain and inflammation management. Ongoing post-marketing surveillance studies continue to assess long-term safety and rare adverse events.
Lab Monitoring
- Renal function tests (creatinine, BUN) for long-term use
- Liver function tests (ALT, AST) periodically
- Complete blood count (CBC) to monitor for anemia with prolonged therapy
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before prescribing.
- Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor renal function, blood pressure, and CBC with long-term therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Take with food or milk to reduce stomach upset.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking this medicine as it may increase the risk of stomach bleeding.
- Stay hydrated by drinking plenty of fluids.
- Report any unusual bleeding or bruising to your doctor immediately.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.