Edin
Generic Name
Etodolac
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| edin 500 mg capsule | ৳ 12.50 | N/A |
Description
Overview of the medicine
Edin-500-mg-capsule contains Etodolac, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness from conditions like osteoarthritis, rheumatoid arthritis, and acute pain.
Uses & Indications
Dosage
Adults
For osteoarthritis and rheumatoid arthritis, 500 mg capsule once or twice daily, up to a maximum of 1200 mg/day. For acute pain, 200-400 mg every 6-8 hours as needed, or 500 mg twice daily; total daily dose should not exceed 1200 mg.
Elderly
Lower initial doses and careful monitoring are recommended due to increased risk of adverse effects, especially GI and renal. Max 1200 mg/day.
Renal_impairment
Use with caution. Dose reduction may be necessary in moderate to severe impairment. Avoid in severe renal disease.
How to Take
Edin-500-mg-capsule should be taken orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the capsule whole with a full glass of water. Do not chew, crush, or break the capsule.
Mechanism of Action
Etodolac acts by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever. By reducing prostaglandin production, Etodolac exerts its anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Onset of analgesic action typically occurs within 30-60 minutes.
Excretion
Primarily excreted through the kidneys (urine) as metabolites, with a small amount excreted in feces.
Half life
Plasma elimination half-life ranges from 6 to 8 hours.
Absorption
Rapidly absorbed from the GI tract after oral administration. Bioavailability is approximately 80%.
Metabolism
Extensively metabolized in the liver via glucuronidation and hydroxylation, forming inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to Etodolac or any other NSAID
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Congestive heart failure (NYHA Class II-IV)
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
- Third trimester of pregnancy
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to lithium toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced natriuretic effect of diuretics.
ACE inhibitors and Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management involves symptomatic and supportive treatment. Gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C in first and second trimesters, D in third trimester. Avoid in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution in first and second trimesters only if potential benefit justifies the potential risk to the fetus. Etodolac is excreted in human milk, so it is not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent (Generic available)
Clinical Trials
Etodolac has undergone extensive clinical trials demonstrating its efficacy and safety for various pain and inflammatory conditions, leading to its widespread approval and use.
Lab Monitoring
- Complete Blood Count (CBC) with differential (especially for long-term therapy)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs - creatinine, BUN)
- Blood Pressure Monitoring (regularly, especially in hypertensive patients)
Doctor Notes
- Educate patients on the potential cardiovascular and gastrointestinal risks associated with NSAID use.
- Prescribe the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
- Monitor patients for signs and symptoms of GI bleeding and cardiovascular adverse events, especially in high-risk individuals.
- Consider gastroprotective agents for patients at high risk of GI complications.
Patient Guidelines
- Always take this medicine exactly as your doctor has told you.
- Take with food or milk to minimize stomach upset.
- Do not exceed the recommended dose or duration of treatment.
- Report any signs of unusual bleeding, severe stomach pain, black stools, or severe skin reactions immediately to your doctor.
- Avoid alcohol while taking this medicine.
- Do not take other NSAIDs or aspirin without consulting your doctor.
Missed Dose Advice
If you miss a dose of Edin-500-mg-capsule, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Edin-500-mg-capsule may cause dizziness, drowsiness, visual disturbances, or fatigue in some patients. If you experience these effects, you should avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Engage in regular, moderate exercise if your condition allows.
- Avoid smoking and excessive alcohol consumption, as these can exacerbate gastrointestinal risks associated with NSAIDs.
- Follow up with your doctor regularly for monitoring, especially during long-term therapy.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.