Edolac-ER
Generic Name
Etodolac Extended-Release
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| edolac er 600 mg tablet | ৳ 18.07 | ৳ 108.42 |
Description
Overview of the medicine
Edolac-ER 600 mg Tablet contains Etodolac, an extended-release non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and acute pain.
Uses & Indications
Dosage
Adults
Oral, 400 mg to 1000 mg once daily. For Edolac-ER 600 mg, typically 600 mg once daily. Max dose 1200 mg/day.
Elderly
Start with lower doses and monitor renal function. Generally, the lowest effective dose should be used.
Renal_impairment
Use with caution. Dosage reduction may be necessary in patients with severe renal impairment. Not recommended in severe renal disease.
How to Take
Take orally once daily. Tablets should be swallowed whole with water and should not be crushed, chewed, or split. Can be taken with or without food.
Mechanism of Action
Etodolac acts by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. By reducing prostaglandin synthesis, it alleviates pain, inflammation, and fever.
Pharmacokinetics
Onset
Analgesic effect typically begins within 1-2 hours for immediate-release, sustained for extended-release.
Excretion
Primarily excreted in the urine (approximately 70% as metabolites) and about 10% in feces.
Half life
Approximately 6-7 hours.
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations of the ER formulation are achieved within 6-12 hours.
Metabolism
Extensively metabolized in the liver primarily via glucuronidation. No significant active metabolites.
Side Effects
Contraindications
- Known hypersensitivity to etodolac or any other NSAID, aspirin, or other components of the formulation.
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
- Active gastrointestinal bleeding or peptic ulcer disease.
- Severe renal or hepatic impairment.
- Third trimester of pregnancy.
Drug Interactions
Lithium
Increased plasma lithium levels, potentially leading to toxicity.
Cyclosporine
Increased risk of nephrotoxicity.
Methotrexate
Increased methotrexate levels and toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet drugs (e.g., Aspirin, Clopidogrel)
Increased risk of gastrointestinal bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Diuretics (e.g., Furosemide, Hydrochlorothiazide)
Reduced diuretic and antihypertensive effects.
ACE Inhibitors / ARBs (Angiotensin Receptor Blockers)
Reduced antihypertensive effects and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of NSAID overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is primarily supportive and symptomatic, with no specific antidote. Gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C in the first and second trimesters, and Category D in the third trimester. Avoid during late pregnancy due to potential fetal cardiovascular effects. Small amounts of etodolac may pass into breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Known hypersensitivity to etodolac or any other NSAID, aspirin, or other components of the formulation.
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
- Active gastrointestinal bleeding or peptic ulcer disease.
- Severe renal or hepatic impairment.
- Third trimester of pregnancy.
Drug Interactions
Lithium
Increased plasma lithium levels, potentially leading to toxicity.
Cyclosporine
Increased risk of nephrotoxicity.
Methotrexate
Increased methotrexate levels and toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Antiplatelet drugs (e.g., Aspirin, Clopidogrel)
Increased risk of gastrointestinal bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Diuretics (e.g., Furosemide, Hydrochlorothiazide)
Reduced diuretic and antihypertensive effects.
ACE Inhibitors / ARBs (Angiotensin Receptor Blockers)
Reduced antihypertensive effects and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of NSAID overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is primarily supportive and symptomatic, with no specific antidote. Gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C in the first and second trimesters, and Category D in the third trimester. Avoid during late pregnancy due to potential fetal cardiovascular effects. Small amounts of etodolac may pass into breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of etodolac in various pain and inflammatory conditions, particularly for osteoarthritis and rheumatoid arthritis, with its extended-release formulation showing sustained therapeutic levels.
Lab Monitoring
- Complete Blood Count (CBC) to monitor for gastrointestinal bleeding.
- Liver Function Tests (LFTs) to monitor for hepatotoxicity.
- Kidney Function Tests (Creatinine, BUN) to monitor for nephrotoxicity.
- Blood pressure monitoring, especially in hypertensive patients.
Doctor Notes
- Prior to prescribing, assess patient's cardiovascular risk factors, including history of hypertension, dyslipidemia, and diabetes.
- Monitor patients for signs and symptoms of GI bleeding, especially those with a history of ulcers or elderly patients.
- Regularly monitor renal and hepatic function during prolonged therapy with NSAIDs.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Report any unusual bleeding, black/tarry stools, or severe stomach pain immediately.
- Report any signs of swelling, unexplained weight gain, or skin rash.
- Avoid alcohol while taking this medicine to reduce the risk of stomach irritation.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, drowsiness, or visual disturbances. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy and balanced diet to support overall health.
- Engage in regular, moderate exercise (as advised by your doctor) to help manage arthritis symptoms.
- Quit smoking to reduce cardiovascular and gastrointestinal risks.
- Limit alcohol intake as it may increase the risk of adverse effects.
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