Edruvit-M
Generic Name
Methylcobalamin + Folic Acid + Pyridoxine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| edruvit m tablet | ৳ 1.50 | N/A |
Description
Overview of the medicine
Edruvit-M Tablet is a combination of Methylcobalamin (Vitamin B12), Folic Acid (Vitamin B9), and Pyridoxine Hydrochloride (Vitamin B6). It is primarily used to support nerve health, improve blood cell formation, and manage deficiencies of these essential B vitamins.
Uses & Indications
Dosage
Adults
Usually 1 tablet daily, or as directed by a physician.
Elderly
No specific dose adjustment is typically required for the elderly, but consult a physician.
Renal_impairment
Generally safe, but for severe impairment, consult a physician.
How to Take
Take orally with water, with or without food. Follow the physician's instructions regarding duration of treatment.
Mechanism of Action
Methylcobalamin plays a crucial role in nerve tissue health, myelin sheath formation, and red blood cell production. Folic acid is essential for DNA synthesis and red blood cell maturation. Pyridoxine HCl is involved in neurotransmitter synthesis, protein metabolism, and hemoglobin formation, supporting overall nervous system function.
Pharmacokinetics
Onset
Therapeutic effects may be noticed within days to weeks depending on the severity of deficiency.
Excretion
Mainly excreted in urine, partially as metabolites and partially unchanged.
Half life
Methylcobalamin: Variable, Pyridoxine: 15-20 days (total body store turnover), Folic Acid: Metabolized to active forms, then eliminated.
Absorption
Methylcobalamin and Folic Acid are readily absorbed from the gastrointestinal tract, primarily in the small intestine. Pyridoxine is also well-absorbed.
Metabolism
Methylcobalamin is metabolically active. Folic acid is reduced to tetrahydrofolate. Pyridoxine is metabolized in the liver to pyridoxal phosphate (active form).
Side Effects
Contraindications
- Hypersensitivity to any of the active ingredients or excipients.
Drug Interactions
Methotrexate
Folic acid can interfere with methotrexate action.
Chloramphenicol
May antagonize the hematological response to Vitamin B12.
Proton Pump Inhibitors (e.g., Omeprazole)
May reduce absorption of Vitamin B12.
Certain antiepileptic drugs (e.g., Phenytoin, Carbamazepine)
May reduce folic acid levels.
Storage
Store in a cool (below 30°C), dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose is rare due to the water-soluble nature of these vitamins. However, very high doses of pyridoxine over a long period can lead to sensory neuropathy. Management involves discontinuation of the product and symptomatic treatment if needed.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation to meet increased nutritional demands, especially for folic acid to prevent neural tube defects. However, always consult a physician before use.
Side Effects
Contraindications
- Hypersensitivity to any of the active ingredients or excipients.
Drug Interactions
Methotrexate
Folic acid can interfere with methotrexate action.
Chloramphenicol
May antagonize the hematological response to Vitamin B12.
Proton Pump Inhibitors (e.g., Omeprazole)
May reduce absorption of Vitamin B12.
Certain antiepileptic drugs (e.g., Phenytoin, Carbamazepine)
May reduce folic acid levels.
Storage
Store in a cool (below 30°C), dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose is rare due to the water-soluble nature of these vitamins. However, very high doses of pyridoxine over a long period can lead to sensory neuropathy. Management involves discontinuation of the product and symptomatic treatment if needed.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation to meet increased nutritional demands, especially for folic acid to prevent neural tube defects. However, always consult a physician before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies, Drugstores
Approval Status
Approved as a dietary supplement/nutritional product
Patent Status
Off-patent
Clinical Trials
While specific brand-related clinical trials may not be extensively publicized for such vitamin combinations, the efficacy of Methylcobalamin, Folic Acid, and Pyridoxine in treating respective deficiencies and neuropathies is well-established through numerous clinical studies.
Lab Monitoring
- Monitoring of Vitamin B12, Folic Acid, and Pyridoxine levels may be done if deficiency is suspected or for treatment efficacy in specific conditions. Complete blood count (CBC) may be monitored for anemia.
Doctor Notes
- Ensure diagnosis of underlying deficiency if present.
- Monitor patient for symptom improvement, especially in neuropathic conditions.
- Advise patients on balanced diet and lifestyle modifications.
Patient Guidelines
- Take the tablet as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about any existing medical conditions or other medications you are taking.
- Store in a cool, dry place away from direct light and moisture.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Edruvit-M is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in vitamins and minerals.
- Limit alcohol consumption.
- Regular exercise can support overall health.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.