Efirel
Generic Name
Efirel 10 mg Tablet
Manufacturer
Reputable Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| efirel 10 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Efirel 10 mg Tablet contains Efirel, a lipid-lowering medication of the statin class. It is primarily used to reduce high cholesterol levels and triglycerides in the blood, thereby lowering the risk of heart attack, stroke, and other heart-related conditions.
Uses & Indications
Dosage
Adults
Initial dose is usually 10 mg once daily. The dose can be adjusted by the physician based on lipid levels and therapeutic response, up to a maximum of 80 mg once daily.
Elderly
No specific dose adjustment is required for elderly patients. However, caution should be exercised, and dose titration should be done carefully.
Renal_impairment
No dose adjustment is necessary for patients with mild to moderate renal impairment. For severe renal impairment, consultation with a physician is recommended.
How to Take
Efirel 10 mg Tablet should be taken orally, once daily. It can be taken any time of the day, with or without food. It is recommended to take it at the same time each day to maintain consistent drug levels.
Mechanism of Action
Efirel selectively inhibits HMG-CoA reductase, an enzyme responsible for cholesterol synthesis in the liver. This inhibition leads to a decrease in hepatic cholesterol, which stimulates the upregulation of LDL receptors on the hepatocyte surface, enhancing the clearance of LDL from the blood.
Pharmacokinetics
Onset
Significant lipid-lowering effects typically observed within 2 weeks; maximum effect within 4 weeks.
Excretion
Primarily excreted in the bile and feces. Less than 2% is excreted in the urine.
Half life
Approximately 14 hours for Efirel, but 20-30 hours for active metabolites, contributing to prolonged activity.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 3A4 (CYP3A4) to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Efirel or any component of the tablet.
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Pregnancy and lactation.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin).
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin; monitor INR closely.
Cyclosporine
Significant increase in Efirel exposure; dose adjustment may be necessary.
Gemfibrozil, other Fibrates
Increased risk of myopathy/rhabdomyolysis when co-administered.
Strong CYP3A4 Inhibitors (e.g., Itraconazole, Ritonavir, Clarithromycin)
Can significantly increase Efirel plasma concentrations, increasing risk of myopathy.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for overdose with Efirel. In the event of an overdose, patients should receive symptomatic and supportive treatment as required. Liver function tests and CK levels should be monitored.
Pregnancy & Lactation
Efirel is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment. If pregnancy occurs, Efirel should be discontinued immediately.
Side Effects
Contraindications
- Hypersensitivity to Efirel or any component of the tablet.
- Active liver disease or unexplained persistent elevations of serum transaminases.
- Pregnancy and lactation.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin).
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin; monitor INR closely.
Cyclosporine
Significant increase in Efirel exposure; dose adjustment may be necessary.
Gemfibrozil, other Fibrates
Increased risk of myopathy/rhabdomyolysis when co-administered.
Strong CYP3A4 Inhibitors (e.g., Itraconazole, Ritonavir, Clarithromycin)
Can significantly increase Efirel plasma concentrations, increasing risk of myopathy.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for overdose with Efirel. In the event of an overdose, patients should receive symptomatic and supportive treatment as required. Liver function tests and CK levels should be monitored.
Pregnancy & Lactation
Efirel is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment. If pregnancy occurs, Efirel should be discontinued immediately.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Efirel, as an HMG-CoA reductase inhibitor, has been extensively studied in numerous large-scale clinical trials demonstrating its efficacy in reducing LDL-C and cardiovascular event rates in various patient populations.
Lab Monitoring
- Liver Function Tests (LFTs): Before initiation of treatment and periodically thereafter, or as clinically indicated.
- Lipid Panel: At baseline and 2-4 weeks after initiating or titrating Efirel, then periodically.
- Creatine Kinase (CK) levels: In patients presenting with muscle pain or weakness.
Doctor Notes
- Emphasize the importance of lifestyle modifications (diet, exercise) alongside Efirel therapy.
- Educate patients on symptoms of myopathy (muscle pain, weakness) and the need to report them promptly.
- Monitor liver enzymes and lipid profile regularly as per guidelines.
Patient Guidelines
- Take Efirel exactly as prescribed by your doctor.
- Continue with your cholesterol-lowering diet and exercise program while taking this medicine.
- Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Efirel generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, you should not drive or perform hazardous tasks.
Lifestyle Advice
- Maintain a healthy diet low in saturated and trans fats.
- Engage in regular physical activity.
- Avoid smoking and limit alcohol consumption.
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