Elidox
Generic Name
Doxycycline
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| elidox 100 mg capsule | ৳ 2.00 | N/A |
Description
Overview of the medicine
Doxycycline is a broad-spectrum antibiotic used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, and certain sexually transmitted diseases.
Uses & Indications
Dosage
Adults
Standard dose: 100 mg orally once or twice daily. For severe infections, 100 mg every 12 hours. For acne: 50-100 mg daily.
Elderly
No specific dose adjustment required based on age alone, but renal/hepatic function should be considered for co-morbidities.
Renal_impairment
No dose adjustment is usually needed for patients with renal impairment due to major non-renal excretion pathway.
How to Take
Take with a full glass of water (at least 240 mL), preferably while sitting or standing, to prevent esophageal irritation and ulceration. Do not lie down for at least 30 minutes after taking the capsule. Can be taken with food to minimize gastric upset, but avoid dairy products and antacids.
Mechanism of Action
Doxycycline inhibits bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit, thereby preventing the attachment of aminoacyl tRNA to the A site on the ribosome.
Pharmacokinetics
Onset
Antibacterial effect typically observed within hours of administration.
Excretion
Primarily via urine (approx. 40%) and feces (approx. 60%) as inactive compounds.
Half life
16-22 hours, allowing for once or twice daily dosing.
Absorption
Well absorbed orally, generally 90-100% bioavailability. Peak plasma concentrations are reached within 1.5-4 hours.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to doxycycline or other tetracyclines.
- Pregnancy (especially 2nd and 3rd trimesters) and breastfeeding.
- Children under 8 years of age (risk of permanent tooth discoloration and enamel hypoplasia).
Drug Interactions
Warfarin
Doxycycline may potentiate the anticoagulant effect of warfarin. Monitor INR closely.
Penicillins
Tetracyclines can interfere with the bactericidal action of penicillins. Avoid concomitant use.
Oral contraceptives
May reduce the effectiveness of oral contraceptives. Advise alternative or additional birth control methods.
Barbiturates, Carbamazepine, Phenytoin
May decrease the half-life of doxycycline, potentially reducing its effectiveness.
Antacids, Iron supplements, Bismuth subsalicylate
These can decrease the absorption of doxycycline. Separate administration by at least 2-3 hours.
Storage
Store in a cool, dry place below 30°C. Protect from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, and diarrhea. Management involves gastric lavage and symptomatic and supportive treatment. Dialysis is generally not effective in removing doxycycline from the body.
Pregnancy & Lactation
Doxycycline is contraindicated during pregnancy due to the risk of permanent discoloration of developing teeth and reversible inhibition of bone growth in the fetus. It is also not recommended during breastfeeding as it passes into breast milk and may affect the infant's teeth and bones.
Side Effects
Contraindications
- Hypersensitivity to doxycycline or other tetracyclines.
- Pregnancy (especially 2nd and 3rd trimesters) and breastfeeding.
- Children under 8 years of age (risk of permanent tooth discoloration and enamel hypoplasia).
Drug Interactions
Warfarin
Doxycycline may potentiate the anticoagulant effect of warfarin. Monitor INR closely.
Penicillins
Tetracyclines can interfere with the bactericidal action of penicillins. Avoid concomitant use.
Oral contraceptives
May reduce the effectiveness of oral contraceptives. Advise alternative or additional birth control methods.
Barbiturates, Carbamazepine, Phenytoin
May decrease the half-life of doxycycline, potentially reducing its effectiveness.
Antacids, Iron supplements, Bismuth subsalicylate
These can decrease the absorption of doxycycline. Separate administration by at least 2-3 hours.
Storage
Store in a cool, dry place below 30°C. Protect from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, and diarrhea. Management involves gastric lavage and symptomatic and supportive treatment. Dialysis is generally not effective in removing doxycycline from the body.
Pregnancy & Lactation
Doxycycline is contraindicated during pregnancy due to the risk of permanent discoloration of developing teeth and reversible inhibition of bone growth in the fetus. It is also not recommended during breastfeeding as it passes into breast milk and may affect the infant's teeth and bones.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
FDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Doxycycline has been extensively studied in numerous clinical trials for its efficacy and safety in treating a wide range of bacterial infections. It is a well-established and widely used antibiotic.
Lab Monitoring
- Periodic liver and kidney function tests for patients on prolonged therapy.
- Complete blood count (CBC) may be monitored occasionally.
Doctor Notes
- Emphasize proper administration (with water, upright position) to mitigate esophageal adverse effects.
- Counsel patients on photosensitivity precautions.
- Stress the importance of completing the full antibiotic course to prevent resistance and recurrence.
Patient Guidelines
- Take with a full glass of water and remain upright for at least 30 minutes to prevent esophageal irritation.
- Avoid prolonged exposure to direct sunlight or artificial UV light; use sunscreen and wear protective clothing.
- Complete the entire prescribed course of treatment, even if symptoms improve, to prevent antibiotic resistance.
- Inform your doctor if you experience severe headaches, vision changes, or severe diarrhea.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to catch up.
Driving Precautions
Doxycycline may cause dizziness or visual disturbances in some individuals. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Stay well-hydrated.
- Avoid excessive alcohol consumption, as it may exacerbate side effects.
- Maintain good oral hygiene.
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Global Brand Names
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