Elipta
Generic Name
Sertraline
Manufacturer
Alpha Pharmaceuticals (Hypothetical)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| elipta 25 mg tablet | ৳ 40.00 | ৳ 400.00 |
Description
Overview of the medicine
Elipta 25 mg Tablet contains Sertraline, an antidepressant used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, and social anxiety disorder, among others.
Uses & Indications
Dosage
Adults
Initial: 25-50 mg once daily. May be increased gradually by 25-50 mg at weekly intervals to a maximum of 200 mg daily.
Elderly
Similar to adults, but starting with a lower dose (e.g., 25 mg) and slower titration may be considered due to potential for decreased clearance.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Caution is advised in severe renal impairment.
How to Take
Take orally once daily, with or without food. It is generally recommended to take it at the same time each day.
Mechanism of Action
Sertraline selectively inhibits the reuptake of serotonin (5-HT) by presynaptic neurons, leading to an increase in the concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission.
Pharmacokinetics
Onset
Therapeutic effects typically begin within 2 to 4 weeks, with full effect potentially taking longer.
Excretion
Approximately 40-45% excreted in urine and 40-45% in feces, primarily as metabolites.
Half life
Approximately 26 hours for sertraline, and 62 to 104 hours for its active metabolite, N-desmethylsertraline.
Absorption
Well absorbed orally; peak plasma concentrations achieved 4.5 to 8.4 hours post-dose. Bioavailability is approximately 44%.
Metabolism
Extensively metabolized in the liver via multiple cytochrome P450 enzymes (CYP2D6, CYP2C19, CYP3A4, CYP2B6, CYP2C9) to N-desmethylsertraline, which is less active.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy (risk of serotonin syndrome).
- Concomitant use with pimozide.
- Known hypersensitivity to sertraline or any component of the formulation.
- Concomitant use with disulfiram (for oral solution formulation due to alcohol content).
Drug Interactions
MAOIs
Risk of serious, sometimes fatal, serotonin syndrome.
Lithium
Potential for increased tremor.
Pimozide
Increased pimozide levels and potential for QT prolongation.
Triptans
Risk of serotonin syndrome.
Warfarin
May increase prothrombin time/INR, leading to increased bleeding risk.
NSAIDs/Aspirin
Increased risk of bleeding.
Tricyclic Antidepressants (TCAs)
Potential for increased TCA levels.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and rarely, seizures. Management involves supportive care, maintaining an open airway, monitoring cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Sertraline is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy (risk of serotonin syndrome).
- Concomitant use with pimozide.
- Known hypersensitivity to sertraline or any component of the formulation.
- Concomitant use with disulfiram (for oral solution formulation due to alcohol content).
Drug Interactions
MAOIs
Risk of serious, sometimes fatal, serotonin syndrome.
Lithium
Potential for increased tremor.
Pimozide
Increased pimozide levels and potential for QT prolongation.
Triptans
Risk of serotonin syndrome.
Warfarin
May increase prothrombin time/INR, leading to increased bleeding risk.
NSAIDs/Aspirin
Increased risk of bleeding.
Tricyclic Antidepressants (TCAs)
Potential for increased TCA levels.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and rarely, seizures. Management involves supportive care, maintaining an open airway, monitoring cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Sertraline is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 24-36 months from the date of manufacture, specific to batch.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved, DGDA Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Sertraline has undergone extensive clinical trials demonstrating efficacy and safety for its approved indications, including studies on long-term use and specific patient populations.
Lab Monitoring
- Monitor serum electrolytes (especially sodium) if hyponatremia is suspected.
- Periodically monitor liver function tests (LFTs), particularly in patients with hepatic impairment.
- Monitor for signs of bleeding, especially with concomitant use of anticoagulants or antiplatelet agents.
Doctor Notes
- Counsel patients regarding the delayed onset of action and the importance of continued treatment.
- Educate patients and caregivers about the Black Box Warning regarding suicidal ideation.
- Monitor for signs of serotonin syndrome, especially when co-administered with other serotonergic agents.
- Regularly assess for drug interactions, particularly with warfarin, MAOIs, and pimozide.
Patient Guidelines
- Take Elipta exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly, as this can lead to withdrawal symptoms. Consult your doctor before discontinuation.
- Report any worsening of depression, suicidal thoughts, or unusual changes in behavior to your doctor immediately.
- Avoid alcohol while taking this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double dose.
Driving Precautions
Elipta may cause dizziness, drowsiness, or visual disturbances. Use caution when driving or operating machinery until you know how the medication affects you.
Lifestyle Advice
- Maintain a regular sleep schedule and practice good sleep hygiene.
- Engage in regular physical activity.
- Eat a balanced diet.
- Avoid excessive caffeine and alcohol.
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Global Brand Names
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