Eliquis
Generic Name
Apixaban
Manufacturer
Bristol-Myers Squibb, Pfizer
Country
USA, Europe
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Description
Overview of the medicine
Apixaban is an anticoagulant used to prevent blood clots.
Uses & Indications
Dosage
Adults
5 mg twice daily, unless specific criteria are met for dose reduction.
Elderly
May require dose reduction based on age, weight, and renal function.
Renal_impairment
2.5 mg twice daily if at least two of the following criteria are met: age ≥80 years, body weight ≤60 kg, or serum creatinine ≥1.5 mg/dL.
How to Take
Oral administration, with or without food.
Mechanism of Action
Selectively inhibits free and clot-bound factor Xa, as well as prothrombinase activity.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Renal and fecal excretion.
Half life
Approximately 12 hours.
Absorption
Rapidly absorbed, bioavailability is approximately 50%.
Metabolism
Primarily metabolized by CYP3A4/5.
Side Effects
Contraindications
- •Active pathological bleeding
- •Severe hypersensitivity to apixaban
Drug Interactions
Strong CYP3A4 and P-gp inducers (e.g., rifampin, phenytoin, carbamazepine)
Decreased apixaban levels
Strong CYP3A4 and P-gp inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin)
Increased apixaban levels
Storage
Store at room temperature, away from moisture and light.
Overdose
There is no specific antidote. General supportive measures should be implemented. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy: Use with caution, benefits should outweigh risks. Lactation: Not recommended due to potential risk to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved, DGDA Approved
Patent Status
Patented
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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