Elisa
Generic Name
Eszopiclone
Manufacturer
Fictional Pharma Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| elisa 3 mg tablet | ৳ 425.04 | N/A |
Description
Overview of the medicine
Elisa 3 mg Tablet contains Eszopiclone, a non-benzodiazepine hypnotic, used for the short-term treatment of insomnia. It helps individuals fall asleep faster and stay asleep longer.
Uses & Indications
Dosage
Adults
The recommended starting dose is 1 mg. The dose can be increased to 2 mg or 3 mg if clinically indicated. Should be taken immediately before bedtime. Maximum recommended dose is 3 mg.
Elderly
For elderly or debilitated patients, the recommended starting dose is 1 mg immediately before bedtime. Dosage should not exceed 2 mg.
Renal_impairment
No dose adjustment is required for mild to moderate renal impairment. Use with caution in severe renal impairment (starting dose 1 mg).
How to Take
Administer orally immediately before bedtime. Take with or without food. Avoid taking with a heavy, high-fat meal as it may delay absorption.
Mechanism of Action
Eszopiclone is a non-benzodiazepine hypnotic that is a pyrrolopyrazine derivative of the cyclopyrrolone class. It is thought to act by interacting with GABA-A receptor complexes at binding domains close to or allosterically coupled to benzodiazepine receptors, thereby enhancing the inhibitory effects of GABA.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Excreted primarily in urine (up to 75%) and feces (20-25%) as metabolites.
Half life
Approximately 6 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached within approximately 1 hour.
Metabolism
Extensively metabolized by oxidation and demethylation via CYP3A4 and CYP2E1 enzymes.
Side Effects
Contraindications
- Hypersensitivity to eszopiclone or any component of the formulation.
- Patients with severe hepatic impairment.
- Concomitant use with strong CYP3A4 inhibitors (unless dose adjusted).
- Patients with complex sleep behaviors (e.g., sleepwalking, sleep-driving) after taking eszopiclone.
Drug Interactions
Alcohol
Additive CNS depressant effects.
Other CNS depressants (e.g., benzodiazepines, opioids)
Increased risk of sedation and respiratory depression.
Strong CYP3A4 inducers (e.g., rifampin, carbamazepine)
Can decrease eszopiclone exposure, reducing efficacy.
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
Can significantly increase eszopiclone exposure, requiring dose reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, ataxia, slurred speech, and respiratory depression. Management includes general supportive measures, gastric lavage if appropriate, and monitoring of vital signs. Flumazenil may be considered in severe cases, but its use is not routinely recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the potential risk to the fetus. Eszopiclone is excreted in breast milk; therefore, use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to eszopiclone or any component of the formulation.
- Patients with severe hepatic impairment.
- Concomitant use with strong CYP3A4 inhibitors (unless dose adjusted).
- Patients with complex sleep behaviors (e.g., sleepwalking, sleep-driving) after taking eszopiclone.
Drug Interactions
Alcohol
Additive CNS depressant effects.
Other CNS depressants (e.g., benzodiazepines, opioids)
Increased risk of sedation and respiratory depression.
Strong CYP3A4 inducers (e.g., rifampin, carbamazepine)
Can decrease eszopiclone exposure, reducing efficacy.
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
Can significantly increase eszopiclone exposure, requiring dose reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, ataxia, slurred speech, and respiratory depression. Management includes general supportive measures, gastric lavage if appropriate, and monitoring of vital signs. Flumazenil may be considered in severe cases, but its use is not routinely recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the potential risk to the fetus. Eszopiclone is excreted in breast milk; therefore, use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Patent expired
Clinical Trials
Numerous clinical trials have demonstrated the efficacy of eszopiclone in improving sleep latency, sleep maintenance, and total sleep time in patients with chronic insomnia. Studies have shown its effectiveness in adults and elderly populations.
Lab Monitoring
- Liver function tests (periodically in patients with hepatic impairment).
- Renal function tests (periodically in patients with renal impairment).
Doctor Notes
- Carefully assess patients for comorbid psychiatric conditions before prescribing.
- Advise patients on the importance of limiting use to short durations to minimize dependence risk.
- Monitor for signs of complex sleep behaviors and educate patients on their potential occurrence.
Patient Guidelines
- Take exactly as prescribed, immediately before going to bed.
- Do not take more than the prescribed dose.
- Ensure you have 7-8 hours available for sleep after taking the medication.
- Do not drink alcohol while taking this medication.
- Report any unusual sleep behaviors to your doctor immediately.
Missed Dose Advice
If a dose is missed, do not take it unless you still have several hours available for sleep. Do not double the dose to make up for a missed one.
Driving Precautions
May cause dizziness, somnolence, and impaired coordination. Do not drive or operate machinery until you know how this medication affects you, and you are fully awake.
Lifestyle Advice
- Practice good sleep hygiene (e.g., consistent bedtime, comfortable sleep environment).
- Avoid caffeine and heavy meals close to bedtime.
- Engage in regular physical activity, but not too close to bedtime.
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