Emedox
Generic Name
Esomeprazole
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| emedox 20 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Emedox 20 mg Tablet contains Esomeprazole, a proton pump inhibitor used to reduce stomach acid production. It is commonly prescribed for conditions like gastroesophageal reflux disease (GERD), stomach ulcers, and other conditions involving excessive stomach acid.
Uses & Indications
Dosage
Adults
GERD: 20 mg or 40 mg once daily for 4-8 weeks. Erosive Esophagitis: 20 mg or 40 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted as needed.
Elderly
No specific dosage adjustment is generally required for elderly patients, but caution is advised due to potential age-related decrease in renal or hepatic function.
Renal_impairment
No dosage adjustment is needed for patients with renal impairment.
Hepatic_impairment
For severe hepatic impairment (Child-Pugh Class C), a maximum dose of 20 mg once daily should not be exceeded.
How to Take
Take the tablet whole with a glass of water, at least one hour before a meal. Do not crush or chew the tablet.
Mechanism of Action
Esomeprazole works by irreversibly blocking the proton pump (H+/K+-ATPase) in the parietal cells of the stomach lining. This action reduces the secretion of gastric acid, providing relief from acid-related symptoms and allowing healing of the esophagus and stomach.
Pharmacokinetics
Onset
Within 1 hour, full effect achieved within 2-3 days of daily dosing.
Excretion
Mainly excreted in urine (approximately 80%) and feces (approximately 20%) as inactive metabolites.
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma levels reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
May decrease the clearance of diazepam.
Warfarin
Increased INR and prothrombin time, monitor closely.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase methotrexate levels, requiring dose adjustment.
Drugs dependent on gastric pH for absorption (e.g., ketoconazole, iron salts)
Reduced absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and increased stomach acid secretion. Management is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm, but human data is limited. Use only if clearly needed. Excreted in breast milk; caution advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
May decrease the clearance of diazepam.
Warfarin
Increased INR and prothrombin time, monitor closely.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase methotrexate levels, requiring dose adjustment.
Drugs dependent on gastric pH for absorption (e.g., ketoconazole, iron salts)
Reduced absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and increased stomach acid secretion. Management is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm, but human data is limited. Use only if clearly needed. Excreted in breast milk; caution advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Ongoing research continues to explore its full therapeutic potential.
Lab Monitoring
- Periodic monitoring of magnesium levels in patients on long-term therapy or with concomitant use of other drugs like diuretics.
- Consider Vitamin B12 levels in long-term use.
- Liver function tests for patients with severe hepatic impairment.
Doctor Notes
- Assess need for long-term therapy and consider lowest effective dose.
- Review concomitant medications for potential interactions.
- Advise patients on lifestyle modifications to complement therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Emedox 20 mg Tablet is generally not expected to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Avoid foods and beverages that trigger acid reflux (e.g., spicy foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce nighttime reflux.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.