Emestop
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| emestop 40 mg capsule | ৳ 50.00 | ৳ 200.00 |
Description
Overview of the medicine
Emestop 40 mg Capsule contains Omeprazole, a proton pump inhibitor used to reduce stomach acid production. It is used to treat conditions such as heartburn, acid reflux, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Ulcers: 20 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial 60 mg once daily, adjusted as needed.
Elderly
No specific dosage adjustment is required, but caution is advised in very frail patients.
Renal_impairment
No dosage adjustment necessary.
How to Take
Take the capsule whole with water at least 30 minutes before a meal, preferably in the morning. Do not chew or crush.
Mechanism of Action
Omeprazole irreversibly blocks the H+/K+-ATPase enzyme system (the 'proton pump') in the gastric parietal cells, thereby inhibiting the final step in acid production.
Pharmacokinetics
Onset
Within 1 hour; maximal effect within 2 hours.
Excretion
Mainly excreted in urine (approx. 80%) and feces (approx. 20%) as metabolites.
Half life
Approximately 0.5-1 hour.
Absorption
Rapidly absorbed from the gastrointestinal tract, bioavailability is about 30-40% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or other substituted benzimidazoles
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased digoxin absorption due to decreased gastric acidity.
Warfarin
Increased INR and prothrombin time. Monitor closely.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel. Consider alternative antiplatelet therapy or a different PPI.
Methotrexate
May increase methotrexate levels and toxicity, especially with high doses.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Excreted in breast milk, use with caution.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or other substituted benzimidazoles
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased digoxin absorption due to decreased gastric acidity.
Warfarin
Increased INR and prothrombin time. Monitor closely.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel. Consider alternative antiplatelet therapy or a different PPI.
Methotrexate
May increase methotrexate levels and toxicity, especially with high doses.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Excreted in breast milk, use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of omeprazole in various acid-related disorders.
Lab Monitoring
- Magnesium levels (with long-term use)
- Vitamin B12 levels (with long-term use)
- INR for patients on warfarin
Doctor Notes
- Educate patients on proper administration and potential long-term risks.
- Consider lowest effective dose for shortest duration.
- Monitor for hypomagnesemia and B12 deficiency in chronic users.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Omeprazole usually does not affect the ability to drive or operate machinery, but if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Elevate the head of your bed.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Emestop Brand
Other medicines available under the same brand name
