Empadus
Generic Name
Empagliflozin
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| empadus 25 mg tablet | ৳ 40.00 | ৳ 560.00 |
Description
Overview of the medicine
Empadus 25 mg Tablet contains Empagliflozin, an SGLT2 inhibitor used for the treatment of type 2 diabetes mellitus, heart failure, and chronic kidney disease.
Uses & Indications
Dosage
Adults
For Type 2 Diabetes: Initial dose is 10 mg once daily, taken in the morning, with or without food. May be increased to 25 mg once daily if needed. For Heart Failure/CKD: 10 mg once daily.
Elderly
No dose adjustment generally required based on age alone. Monitor renal function.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. Not recommended for eGFR < 20 mL/min/1.73 m².
How to Take
Take orally once daily in the morning, with or without food.
Mechanism of Action
Empagliflozin inhibits sodium-glucose co-transporter 2 (SGLT2) in the kidneys, reducing glucose reabsorption from the glomerular filtrate and lowering the renal threshold for glucose. This leads to increased urinary glucose excretion, which lowers plasma glucose concentrations.
Pharmacokinetics
Onset
Within 30 minutes (glucose lowering effect).
Excretion
Primarily excreted via the urine (approx. 50%) and feces (approx. 50%).
Half life
Approximately 12 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in 1.5 hours.
Metabolism
Extensively metabolized by glucuronidation.
Side Effects
Contraindications
- •Hypersensitivity to empagliflozin or any excipients.
- •Severe renal impairment (eGFR < 20 mL/min/1.73 m²), end-stage renal disease, or dialysis.
Drug Interactions
Lithium
SGLT2 inhibitors may decrease serum lithium concentrations.
Diuretics
May increase the risk of dehydration and hypotension.
Insulin and Insulin Secretagogues (e.g., Sulfonylureas)
Increased risk of hypoglycemia, may require dose reduction of insulin/sulfonylurea.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment should be initiated. Empagliflozin is not removed by dialysis.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the second and third trimesters. It is unknown if empagliflozin is excreted in human milk; use is not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved, DGDA Approved
Patent Status
Patented
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Global Brand Names
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