Emprila
Generic Name
Corticosteroid A 2.5% and Antifungal B 2.5% Topical Cream
Manufacturer
PharmaGlobal Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| emprila 25 25 cream | ৳ 130.00 | N/A |
Description
Overview of the medicine
Emprila-25-25-Cream is a topical medication combining a corticosteroid (Corticosteroid A 2.5%) and an antifungal agent (Antifungal B 2.5%). It is used to treat various inflammatory and fungal skin conditions where both anti-inflammatory and antifungal actions are required.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area twice daily, preferably in the morning and evening. Treatment duration should not exceed 2-4 weeks without medical review.
Elderly
No specific dosage adjustment required; use with caution due to thinner skin and potential increased absorption.
Renal_impairment
No specific dosage adjustment required for topical application.
How to Take
For external use only. Apply a thin film to the clean, dry affected skin and gently rub in. Avoid contact with eyes, mouth, and other mucous membranes. Wash hands thoroughly after application.
Mechanism of Action
Corticosteroid A reduces inflammation, pruritus, and vasoconstriction through its anti-inflammatory and immunosuppressive properties. Antifungal B exerts its fungicidal or fungistatic action by disrupting fungal cell membrane permeability, leading to fungal cell death or inhibition of growth.
Pharmacokinetics
Onset
Symptomatic relief of itching and inflammation usually begins within a few days of regular application.
Excretion
Systemically absorbed metabolites are mainly excreted via the kidneys (urine) and to a lesser extent in the feces.
Half life
Not clinically significant for topical application due to minimal systemic absorption; any absorbed corticosteroid is typically metabolized rapidly.
Absorption
Minimal systemic absorption occurs through intact skin. Absorption is increased with damaged skin, occlusion, prolonged use, and application to large surface areas.
Metabolism
Any systemically absorbed corticosteroid is primarily metabolized in the liver to inactive metabolites. Antifungal B, if absorbed, also undergoes hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to any component of the cream
- Viral skin infections (e.g., herpes simplex, varicella)
- Tuberculosis of the skin or syphilitic skin lesions
- Acne rosacea or perioral dermatitis
- Vaccination reactions
Drug Interactions
Immunosuppressants
May enhance the immunosuppressive effect locally, increasing risk of infection.
Systemic Corticosteroids
Increased risk of systemic corticosteroid side effects if used concurrently over large areas or for prolonged periods.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause acute systemic toxicity. Chronic overuse or misuse may lead to local skin atrophy, striae, or rarely, systemic corticosteroid effects like Cushing's syndrome due to increased absorption.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor before use. Avoid extensive use or application to large areas.
Side Effects
Contraindications
- Hypersensitivity to any component of the cream
- Viral skin infections (e.g., herpes simplex, varicella)
- Tuberculosis of the skin or syphilitic skin lesions
- Acne rosacea or perioral dermatitis
- Vaccination reactions
Drug Interactions
Immunosuppressants
May enhance the immunosuppressive effect locally, increasing risk of infection.
Systemic Corticosteroids
Increased risk of systemic corticosteroid side effects if used concurrently over large areas or for prolonged periods.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause acute systemic toxicity. Chronic overuse or misuse may lead to local skin atrophy, striae, or rarely, systemic corticosteroid effects like Cushing's syndrome due to increased absorption.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor before use. Avoid extensive use or application to large areas.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies and Hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Generic available, original patent expired
Clinical Trials
Clinical trials have demonstrated Emprila-25-25-Cream's efficacy in reducing inflammation, pruritus, and fungal load in patients with various inflammatory and fungal dermatoses. Safety profiles indicated mild, transient local adverse events.
Lab Monitoring
- Not routinely required for short-term topical use. In cases of extensive or prolonged use, adrenal function tests might be considered due to potential systemic absorption of corticosteroids.
Doctor Notes
- Educate patients on proper application technique and duration to minimize local and systemic side effects.
- Advise against abrupt discontinuation of long-term corticosteroid therapy.
- Monitor for signs of skin thinning, rebound flare-ups, or secondary infections.
Patient Guidelines
- Use only as directed by your doctor; do not exceed the prescribed duration or amount.
- Avoid applying the cream near the eyes or on mucous membranes.
- Do not cover the treated area with occlusive dressings unless specifically instructed by your doctor.
- Inform your doctor if your condition does not improve within 7-14 days or if it worsens.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Emprila-25-25-Cream is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene to prevent further infections.
- Wear loose-fitting, breathable clothing to minimize irritation.
- Avoid harsh soaps or irritants on the affected skin.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.