Endkof
Generic Name
endkof-75-mg-syrup
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| endkof 75 mg syrup | ৳ 70.00 | N/A |
Description
Overview of the medicine
Endkof 75 mg Syrup is an oral medication formulated to provide relief from cough and associated cold symptoms. It typically combines an expectorant to help thin and loosen mucus, making it easier to clear from the airways, with an antitussive to suppress the cough reflex, offering comprehensive relief from various types of coughs.
Uses & Indications
Dosage
Adults
10-20 ml (2-4 teaspoonfuls) orally every 4-6 hours as needed, not to exceed 120 ml in 24 hours.
Elderly
Same as adult dose, but caution is advised. Consult a doctor for personalized advice.
Renal_impairment
Use with caution. Dosage adjustment may be necessary in severe renal impairment. Consult a physician.
How to Take
For oral administration only. Shake the bottle well before use. Use a calibrated measuring spoon or cup provided with the package to ensure accurate dosing. Do not exceed the recommended dose.
Mechanism of Action
The expectorant component (e.g., Guaifenesin) works by increasing the volume and decreasing the viscosity of respiratory tract secretions, facilitating their removal by coughing. The antitussive component (e.g., Dextromethorphan) acts centrally on the cough center in the medulla, elevating the cough threshold and thus reducing the frequency and intensity of coughing.
Pharmacokinetics
Onset
Onset of action typically occurs within 15-60 minutes.
Excretion
Mainly excreted in urine as metabolites and, to a lesser extent, as unchanged drug.
Half life
Approximately 1-4 hours, depending on the specific active ingredient.
Absorption
Both expectorant and antitussive components are generally well absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver, often by CYP450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to any active ingredient or excipient in the syrup
- Patients with persistent or chronic cough (e.g., due to asthma, smoking, emphysema) or cough accompanied by excessive phlegm, unless directed by a doctor
- Children under 2 years of age without medical supervision
Drug Interactions
Alcohol and CNS Depressants
May increase drowsiness, dizziness, and central nervous system depression.
Other Cough/Cold Medications
Avoid concurrent use with other products containing similar active ingredients to prevent overdose.
Monoamine Oxidase Inhibitors (MAOIs)
Potential for serious adverse reactions (e.g., serotonin syndrome) if an antitussive like Dextromethorphan is present and taken within 2 weeks of MAOIs.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include severe nausea, vomiting, dizziness, drowsiness, confusion, rapid heartbeat, respiratory depression, or excitation. In case of suspected overdose, seek immediate medical attention or contact a poison control center.
Pregnancy & Lactation
Consult a doctor before use if you are pregnant, planning to become pregnant, or breastfeeding. While generally considered low risk for short-term use, medical advice is recommended to ensure safety for both mother and baby.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Specific clinical trial data for 'Endkof 75 mg Syrup' may be proprietary to the manufacturer. However, the active ingredients commonly found in such formulations (e.g., guaifenesin, dextromethorphan) have extensive clinical evidence supporting their efficacy and safety.
Lab Monitoring
- Routine lab monitoring is generally not required for short-term, recommended use of this syrup.
- In patients with underlying hepatic or renal impairment, or with prolonged use, liver and kidney function tests may be considered.
Doctor Notes
- Always assess the nature of the cough (productive vs. dry) and duration before recommending.
- Caution advised for patients with chronic respiratory conditions like asthma or COPD.
- Advise patients against self-medication for prolonged cough; investigate underlying causes.
Patient Guidelines
- Always read and follow the directions on the label carefully.
- Do not use for persistent or chronic cough without consulting a doctor.
- If symptoms do not improve within 7 days or worsen, consult your doctor or pharmacist.
- Keep this and all medicines out of the sight and reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause drowsiness or dizziness in some individuals. Exercise caution when driving or operating machinery until you know how Endkof 75 mg Syrup affects you.
Lifestyle Advice
- Stay well-hydrated by drinking plenty of fluids, which can help thin mucus.
- Avoid exposure to smoke, dust, and other environmental irritants that can worsen cough.
- Get adequate rest to support your body's recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.