Enol
Generic Name
Etodolac
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| enol 50 mg tablet | ৳ 0.77 | N/A |
Description
Overview of the medicine
Enol 50 mg Tablet contains Etodolac, a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and stiffness associated with various conditions such as osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. It works by blocking the production of certain natural substances in the body that cause inflammation.
Uses & Indications
Dosage
Adults
For osteoarthritis/rheumatoid arthritis: 300 mg two to three times daily, or 400-500 mg twice daily; total daily dose should not exceed 1000 mg. For acute pain: 200-400 mg every 6-8 hours as needed; total daily dose should not exceed 1000 mg.
Elderly
Start with the lowest effective dose and monitor for adverse effects, especially gastrointestinal. Dosage adjustment may be required.
Renal_impairment
Use with caution; dosage adjustment may be necessary. Avoid in severe renal impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break.
Mechanism of Action
Etodolac exerts its anti-inflammatory, analgesic, and antipyretic actions primarily through the inhibition of prostaglandin synthesis by reversible inhibition of cyclooxygenase (COX-1 and COX-2) enzymes. It shows a degree of selectivity for COX-2 inhibition compared to some other NSAIDs, especially at lower doses.
Pharmacokinetics
Onset
Within 30-60 minutes for analgesia.
Excretion
Primarily excreted in urine (about 60% as metabolites) and feces (about 34% as metabolites).
Half life
Approximately 6-7 hours.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations achieved in 1-2 hours.
Metabolism
Primarily metabolized in the liver via glucuronidation and hydroxylation.
Side Effects
Contraindications
- Known hypersensitivity to Etodolac or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Third trimester of pregnancy
- Severe renal or hepatic impairment
Drug Interactions
Lithium
Increased plasma lithium levels.
SSRIs/SNRIs
Increased risk of GI bleeding.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration and bleeding.
ACE inhibitors/ARBs
Increased risk of renal impairment and reduced antihypertensive effect.
Other NSAIDs/Aspirin
Increased risk of adverse effects, especially GI.
Cyclosporine/Tacrolimus
Increased risk of nephrotoxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive and symptomatic treatment, including gastric lavage or activated charcoal if ingestion is recent. Monitor renal function and electrolyte balance.
Pregnancy & Lactation
Pregnancy Category C (D in the third trimester). Avoid use in late pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use during lactation should be done with caution; small amounts may be excreted in breast milk. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to Etodolac or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Third trimester of pregnancy
- Severe renal or hepatic impairment
Drug Interactions
Lithium
Increased plasma lithium levels.
SSRIs/SNRIs
Increased risk of GI bleeding.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration and bleeding.
ACE inhibitors/ARBs
Increased risk of renal impairment and reduced antihypertensive effect.
Other NSAIDs/Aspirin
Increased risk of adverse effects, especially GI.
Cyclosporine/Tacrolimus
Increased risk of nephrotoxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive and symptomatic treatment, including gastric lavage or activated charcoal if ingestion is recent. Monitor renal function and electrolyte balance.
Pregnancy & Lactation
Pregnancy Category C (D in the third trimester). Avoid use in late pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use during lactation should be done with caution; small amounts may be excreted in breast milk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies worldwide, including FDA and DGDA.
Patent Status
Generic available (patent expired)
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of Etodolac in various pain and inflammatory conditions, comparing it to placebo and other NSAIDs. Ongoing research continues to explore its cardiovascular and gastrointestinal safety profile.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
- Blood pressure monitoring
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs of GI bleeding, cardiovascular events, and renal toxicity.
- Exercise caution in patients with a history of hypertension, heart failure, or impaired renal/hepatic function.
- Consider co-administration of gastroprotective agents (e.g., PPIs) for patients at high risk of GI complications.
Patient Guidelines
- Take with food or milk to minimize stomach upset.
- Do not exceed the prescribed dose.
- Inform your doctor about all other medications you are taking.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools) or allergic reactions immediately.
- Avoid alcohol while taking this medicine.
- Do not take other NSAIDs or aspirin without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness. Patients should be cautioned about driving or operating machinery until they are reasonably certain that Etodolac does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking.
- Limit alcohol consumption.
- Manage stress to support overall health.
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