Epicet-XR
Generic Name
Paracetamol (Acetaminophen) Extended Release
Manufacturer
Generic Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| epicet xr 1000 mg tablet | ৳ 45.00 | ৳ 270.00 |
Description
Overview of the medicine
Epicet-XR 1000 mg Tablet contains extended-release Paracetamol, used for the relief of mild to moderate pain and to reduce fever. The extended-release formulation provides prolonged pain relief.
Uses & Indications
Dosage
Adults
One 1000 mg tablet every 6-8 hours as needed. Do not exceed 3000 mg (3 tablets) in 24 hours.
Elderly
Generally, same as adult dose, but caution is advised. Consult a doctor for appropriate dosage.
Renal_impairment
Dosage adjustment may be necessary in severe renal impairment. Consult a doctor.
How to Take
Take the tablet orally with water. Do not crush, chew, or break the extended-release tablet, as this may lead to rapid release and absorption of a potentially toxic dose.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system by inhibiting prostaglandin synthesis, which reduces pain and fever. Its exact mechanism is not fully understood, but it may also involve interaction with the serotonergic system.
Pharmacokinetics
Onset
Onset of action for pain relief is typically 30-60 minutes, with prolonged effect due to XR formulation (up to 8 hours or more).
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Plasma half-life is typically 2-3 hours for immediate release, but extended with XR formulations (up to 4-5 hours or more).
Absorption
Well absorbed from the gastrointestinal tract, though absorption rate may be slower with extended-release formulations.
Metabolism
Primarily metabolized in the liver by conjugation with glucuronide and sulfate. A small amount is metabolized by cytochrome P450 to a toxic intermediate (NAPQI) which is detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity, especially with chronic excessive use.
Warfarin
May increase the anticoagulant effect, leading to an increased risk of bleeding. Monitor INR.
Other Paracetamol-containing products
Increases the risk of overdose and severe liver damage.
Storage
Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, and liver damage. Seek immediate medical attention. Treatment involves administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity, especially with chronic excessive use.
Warfarin
May increase the anticoagulant effect, leading to an increased risk of bleeding. Monitor INR.
Other Paracetamol-containing products
Increases the risk of overdose and severe liver damage.
Storage
Store in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, and liver damage. Seek immediate medical attention. Treatment involves administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Available in pharmacies and retail stores
Approval Status
Approved for general use
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support the efficacy and safety of Paracetamol for pain and fever, with specific trials confirming the extended-release profile of XR formulations.
Lab Monitoring
- Liver function tests (in cases of overdose or suspected chronic toxicity)
- Serum Paracetamol levels (in overdose)
Doctor Notes
- Advise patients to adhere strictly to dosing guidelines and avoid concurrent use of other Paracetamol-containing products to prevent acute liver failure.
- Educate about the signs of liver toxicity and prompt medical attention for overdose.
Patient Guidelines
- Do not exceed the recommended dose or duration of use.
- Avoid taking with other Paracetamol-containing products.
- If pain persists for more than 10 days or fever for more than 3 days, consult a doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Limit alcohol intake while using Paracetamol to reduce the risk of liver damage.
- Maintain adequate hydration.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Epicet-XR Brand
Other medicines available under the same brand name
Epicet-XR
Extended-release Tablet
Epicet-XR
Tablet (Extended Release)
Epicet-XR
Tablet (Extended-Release)