Eplon
Generic Name
Eplerenone
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| eplon 5 mg capsule | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Eplerenone is a selective aldosterone receptor antagonist used to treat high blood pressure and heart failure post-myocardial infarction. This 5 mg capsule formulation provides a lower strength option for specific dosing requirements.
Uses & Indications
Dosage
Adults
For heart failure, typically start with 25 mg once daily, increasing to 50 mg once daily if tolerated. For hypertension, usually 50 mg once daily. For 5mg capsule, multiple capsules will be required to reach the target dose as directed by the physician.
Elderly
Similar to adults, with careful monitoring of renal function and serum potassium levels.
Renal_impairment
Initial dose of 25 mg every other day may be considered if creatinine clearance is 30-50 mL/min. Contraindicated in severe renal impairment (CrCl <30 mL/min).
How to Take
Administer orally, with or without food. Swallow the capsule whole with water.
Mechanism of Action
It selectively binds to the mineralocorticoid receptor, blocking the action of aldosterone, leading to increased sodium and water excretion and potassium retention.
Pharmacokinetics
Onset
Varies, blood pressure reduction usually within 2 weeks for hypertension; clinical benefits in heart failure seen over time.
Excretion
Primarily through urine (67%) and feces (33%), mainly as metabolites.
Half life
Approximately 4-6 hours.
Absorption
Well absorbed, bioavailability ~69%, not significantly affected by food.
Metabolism
Primarily metabolized by CYP3A4, forming inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Eplerenone or any component of the formulation.
- •Hyperkalemia (serum potassium >5.5 mEq/L) at initiation.
- •Severe renal impairment (creatinine clearance <30 mL/min).
- •Moderate to severe hepatic impairment.
- •Co-administration with potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, nelfinavir).
- •Concomitant use with other potassium-sparing diuretics or potassium supplements.
Drug Interactions
Lithium
Eplerenone may reduce renal clearance of lithium, leading to increased lithium levels and potential toxicity.
Cyclosporine, Tacrolimus
Increased risk of hyperkalemia and renal dysfunction.
NSAIDs (Nonsteroidal Anti-Inflammatory Drugs)
May reduce the natriuretic and diuretic effects of eplerenone and increase the risk of hyperkalemia in susceptible patients.
ACE inhibitors and Angiotensin Receptor Blockers (ARBs)
Increased risk of hyperkalemia, especially in patients with renal impairment. Monitor serum potassium closely.
Potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
Significantly increase eplerenone exposure and risk of hyperkalemia. Concomitant use is contraindicated.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Manifestations of overdose are expected to be hyperkalemia, hypotension, or dehydration. Management is symptomatic and supportive; includes gastric lavage, activated charcoal, and monitoring of electrolytes (especially potassium) and vital signs. Hemodialysis is not effective in removing eplerenone.
Pregnancy & Lactation
Limited data on use during pregnancy. Use only if potential benefit justifies potential risk to the fetus, and after consulting a physician. Eplerenone is excreted in rat milk; human data is unknown, so caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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