Eporen
Generic Name
Epoetin Alfa (recombinant human erythropoietin)
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| eporen 3000 iu injection | ৳ 1,454.37 | N/A |
Description
Overview of the medicine
Eporen 3000 IU Injection is a synthetic form of erythropoietin, a hormone naturally produced by the kidneys. It stimulates the bone marrow to produce red blood cells and is used to treat anemia caused by chronic kidney disease, chemotherapy, or certain other conditions.
Uses & Indications
Dosage
Adults
Dosage is highly individualized based on the patient's condition, hemoglobin target, and response. For CKD-related anemia, initial dose typically 50-100 IU/kg three times weekly (IV or SC). Adjust dose to maintain hemoglobin levels between 10-12 g/dL.
Elderly
Similar to adult dosing, but with caution due to potential comorbidities and increased sensitivity to adverse effects. Closely monitor hemoglobin and blood pressure.
Renal_impairment
Primary indication for use. Dosage needs careful titration based on hemoglobin response and target. Iron supplementation is crucial for optimal response.
How to Take
Administer by subcutaneous (SC) or intravenous (IV) injection. Do not shake the vial or pre-filled syringe. Inspect visually for particulate matter and discoloration prior to administration. Do not mix with other drug solutions.
Mechanism of Action
Epoetin alfa binds to erythropoietin receptors on progenitor red blood cells in the bone marrow, stimulating their proliferation and differentiation into mature red blood cells. This process, known as erythropoiesis, increases the red blood cell count, hemoglobin, and hematocrit levels.
Pharmacokinetics
Onset
Hematologic response (e.g., increase in reticulocytes) is usually seen within 2-6 weeks of therapy initiation. Maximum effect on hemoglobin levels may take longer.
Excretion
A small amount of intact epoetin alfa is excreted in the urine. The majority is eliminated through binding to erythropoietin receptors.
Half life
The elimination half-life is approximately 4-13 hours following IV administration and 13-24 hours following SC administration.
Absorption
After subcutaneous (SC) administration, absorption is slow and prolonged, with peak serum concentrations occurring 12-18 hours post-dose. Bioavailability after SC injection is approximately 30-40%. After intravenous (IV) administration, the onset is rapid.
Metabolism
Epoetin alfa is primarily cleared through receptor-mediated endocytosis by erythroid progenitor cells and to a lesser extent, hepatic metabolism.
Side Effects
Contraindications
- Uncontrolled hypertension.
- Pure red cell aplasia (PRCA) unrelated to erythropoietin therapy.
- Known hypersensitivity to epoetin alfa or any component of the formulation.
Drug Interactions
Cyclosporine
Epoetin alfa can decrease blood concentrations of cyclosporine. Close monitoring of cyclosporine levels is recommended.
Iron Supplements
Concomitant iron supplementation is usually necessary to ensure an adequate erythropoietic response, especially in iron-deficient patients.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Do not shake.
Overdose
Overdose of epoetin alfa can lead to polycythemia (excessive red blood cells). Management typically involves phlebotomy (blood letting) to reduce hemoglobin and hematocrit levels. Discontinuation or reduction of epoetin alfa dose may also be necessary.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Epoetin alfa is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Uncontrolled hypertension.
- Pure red cell aplasia (PRCA) unrelated to erythropoietin therapy.
- Known hypersensitivity to epoetin alfa or any component of the formulation.
Drug Interactions
Cyclosporine
Epoetin alfa can decrease blood concentrations of cyclosporine. Close monitoring of cyclosporine levels is recommended.
Iron Supplements
Concomitant iron supplementation is usually necessary to ensure an adequate erythropoietic response, especially in iron-deficient patients.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Do not shake.
Overdose
Overdose of epoetin alfa can lead to polycythemia (excessive red blood cells). Management typically involves phlebotomy (blood letting) to reduce hemoglobin and hematocrit levels. Discontinuation or reduction of epoetin alfa dose may also be necessary.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Epoetin alfa is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored correctly.
Availability
Hospitals, retail pharmacies
Approval Status
Approved
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Epoetin alfa has undergone extensive clinical trials demonstrating its efficacy and safety in various indications, particularly in the management of anemia associated with chronic kidney disease and chemotherapy-induced anemia.
Lab Monitoring
- Hemoglobin and hematocrit levels (at least weekly until stable, then regularly).
- Blood pressure (before and during therapy).
- Iron status (serum ferritin, transferrin saturation) to ensure adequate iron stores.
- Electrolytes, including potassium (due to potential for hyperkalemia).
Doctor Notes
- Closely monitor hemoglobin levels to avoid exceeding target ranges, which can increase cardiovascular risk.
- Ensure adequate iron status prior to and during therapy; iron supplementation is often critical.
- Manage hypertension aggressively, as epoetin alfa can exacerbate blood pressure.
- Educate patients on symptoms of thromboembolic events and the importance of adherence to monitoring schedule.
Patient Guidelines
- Do not shake the injection. Administer exactly as directed by your healthcare provider.
- Monitor your blood pressure regularly and report any significant changes.
- Ensure adequate iron intake, as prescribed by your doctor.
- Report any signs of blood clots immediately (e.g., unusual pain or swelling in limbs, chest pain, shortness of breath).
Missed Dose Advice
If a dose is missed, administer it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
No direct impairment on driving or operating machinery is expected. However, if you experience side effects like headache, seizures, or vision changes, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet rich in iron, folic acid, and vitamin B12.
- Stay well-hydrated.
- Adhere to regular check-ups and prescribed treatments for underlying conditions.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Eporen Brand
Other medicines available under the same brand name
