Erode
Generic Name
Erythromycin 125 mg/5 ml Oral Suspension
Manufacturer
Example Manufacturer (e.g., Square Pharmaceuticals Ltd.)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| erode 125 mg suspension | ৳ 70.17 | N/A |
Description
Overview of the medicine
Erode 125 mg Suspension is an antibiotic medication containing Erythromycin, used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Typically not used for adults in suspension form; adult dosage usually 250-500 mg every 6 hours or 500-1000 mg every 12 hours (tablets/capsules). Pediatric dosage is commonly 30-50 mg/kg/day divided in 2-4 doses.
Elderly
Similar to adult dosage, but caution with hepatic or renal impairment.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment; use with caution in severe impairment.
How to Take
Administer orally, usually 2-4 times daily. Can be taken with or without food, but food may reduce gastrointestinal upset. Shake well before each use. Use a calibrated measuring device.
Mechanism of Action
Erythromycin binds to the 50S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis by blocking the translocation of peptides. This leads to a bacteriostatic effect, preventing bacterial growth and replication.
Pharmacokinetics
Onset
Typically within 1-2 hours.
Excretion
Mainly biliary excretion, with a small amount excreted in urine.
Half life
Approximately 1.5 to 2.5 hours.
Absorption
Well absorbed orally, but absorption is variable and affected by food. Ester forms (e.g., stearate, ethylsuccinate) improve absorption.
Metabolism
Primarily hepatic, via CYP3A4 system.
Side Effects
Contraindications
- Hypersensitivity to erythromycin or other macrolide antibiotics
- Concomitant use with terfenadine, astemizole, cisapride, pimozide, ergotamine, dihydroergotamine due to risk of serious arrhythmias
Drug Interactions
Warfarin
Increased anticoagulant effect, leading to bleeding.
Theophylline
Increased serum levels of theophylline, leading to toxicity.
Statins (e.g., Simvastatin)
Increased risk of myopathy/rhabdomyolysis.
Terfenadine/Astemizole/Cisapride/Pimozide
Increased risk of life-threatening cardiac arrhythmias (QT prolongation). Concomitant use is contraindicated.
Storage
Store dry powder below 30°C. Once reconstituted, store in a refrigerator (2-8°C) and discard unused portion after 7-14 days (check specific product leaflet).
Overdose
Symptoms may include nausea, vomiting, diarrhea, and reversible hearing loss. Management involves supportive care and gastric lavage if ingested recently. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe. Small amounts excreted in breast milk; generally considered compatible with breastfeeding, but monitor infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years unopened; 7-14 days after reconstitution when stored as directed.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Erythromycin has been extensively studied since its discovery in the 1950s. Numerous trials have established its efficacy and safety across various bacterial infections. Recent trials focus on resistance patterns and new formulations.
Lab Monitoring
- Liver function tests (especially with prolonged use or pre-existing liver disease)
- Renal function tests (if suspected impairment)
- ECG monitoring (in patients with cardiac risk factors or concomitant QT-prolonging drugs)
Doctor Notes
- Counsel patients on importance of completing full course to prevent resistance.
- Monitor for potential drug interactions, especially with CYP3A4 inhibitors/substrates.
- Advise patients to shake suspension well before administration and use accurate measuring device.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve.
- Shake the suspension well before each use.
- Use the provided measuring device for accurate dosing.
- Report any severe gastrointestinal upset or signs of allergic reaction.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double dose.
Driving Precautions
Generally safe to drive; however, if you experience dizziness or visual disturbances, avoid driving or operating machinery.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Maintain good hygiene to prevent spread of infection.
- Avoid alcohol, as it may worsen stomach upset.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.