Eromycin-DS
Generic Name
Erythromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| eromycin ds 500 mg tablet | ৳ 10.35 | ৳ 62.10 |
Description
Overview of the medicine
Eromycin-DS 500 mg Tablet is a macrolide antibiotic used to treat a wide range of bacterial infections including respiratory tract infections, skin infections, sexually transmitted infections, and others caused by susceptible organisms.
Uses & Indications
Dosage
Adults
Usually 250 mg to 500 mg every 6 to 12 hours, depending on the severity of the infection. For Eromycin-DS 500 mg, typically 500 mg twice daily for severe infections, or as directed by the physician.
Elderly
No specific dose adjustment is generally required, but caution should be exercised due to potential age-related organ function decline.
Renal_impairment
No dose adjustment is needed for mild to moderate renal impairment. For severe renal impairment, dose adjustment may be considered, though erythromycin is primarily excreted via bile.
How to Take
Eromycin-DS 500 mg Tablet is for oral administration. It can be taken with or without food, but taking it on an empty stomach may improve absorption for certain salt forms like stearate. Swallow the tablet whole with water; do not crush or chew.
Mechanism of Action
Erythromycin binds to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting bacterial protein synthesis. It is generally considered bacteriostatic but may be bactericidal at high concentrations or against highly susceptible organisms.
Pharmacokinetics
Onset
Varies by infection type and severity; generally within hours.
Excretion
Mainly through bile and feces; a small portion is excreted in urine.
Half life
Approximately 1.5 to 2 hours.
Absorption
Well absorbed orally, though bioavailability can vary with the salt form and presence of food. Erythromycin stearate absorption is enhanced when taken on an empty stomach.
Metabolism
Primarily hepatic via the cytochrome P450 system (CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to erythromycin or any other macrolide antibiotic.
- Co-administration with terfenadine, astemizole, cisapride, or pimozide due to the risk of severe cardiac arrhythmias (QT prolongation).
Drug Interactions
Digoxin
Increased digoxin levels, potentially leading to digoxin toxicity.
Warfarin
Increased anticoagulant effect, leading to a higher risk of bleeding.
Ciclosporin
Increased ciclosporin levels and risk of nephrotoxicity.
Theophylline
Increased theophylline levels, potentially leading to toxicity.
Carbamazepine
Increased carbamazepine levels and toxicity.
Oral Contraceptives
May reduce the efficacy of oral contraceptives.
Statins (e.g., simvastatin, lovastatin)
Increased risk of myopathy/rhabdomyolysis due to inhibition of statin metabolism.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe gastrointestinal upset (nausea, vomiting, diarrhea, abdominal pain), and reversible hearing loss (ototoxicity). Treatment is supportive and symptomatic, with gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. Erythromycin is generally considered safe for use during pregnancy, though some studies suggest a possible slight increase in cardiovascular malformations. Small amounts are excreted in breast milk, but it is generally considered compatible with breastfeeding. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to erythromycin or any other macrolide antibiotic.
- Co-administration with terfenadine, astemizole, cisapride, or pimozide due to the risk of severe cardiac arrhythmias (QT prolongation).
Drug Interactions
Digoxin
Increased digoxin levels, potentially leading to digoxin toxicity.
Warfarin
Increased anticoagulant effect, leading to a higher risk of bleeding.
Ciclosporin
Increased ciclosporin levels and risk of nephrotoxicity.
Theophylline
Increased theophylline levels, potentially leading to toxicity.
Carbamazepine
Increased carbamazepine levels and toxicity.
Oral Contraceptives
May reduce the efficacy of oral contraceptives.
Statins (e.g., simvastatin, lovastatin)
Increased risk of myopathy/rhabdomyolysis due to inhibition of statin metabolism.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe gastrointestinal upset (nausea, vomiting, diarrhea, abdominal pain), and reversible hearing loss (ototoxicity). Treatment is supportive and symptomatic, with gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. Erythromycin is generally considered safe for use during pregnancy, though some studies suggest a possible slight increase in cardiovascular malformations. Small amounts are excreted in breast milk, but it is generally considered compatible with breastfeeding. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on storage conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Erythromycin is a well-established antibiotic with extensive historical clinical trial data and post-marketing surveillance demonstrating its efficacy and safety in various bacterial infections.
Lab Monitoring
- Liver function tests (LFTs) should be monitored in patients receiving prolonged or repeated courses of erythromycin, especially if they have pre-existing hepatic impairment.
- Renal function monitoring may be considered in patients with severe renal impairment, although erythromycin is primarily eliminated by non-renal routes.
Doctor Notes
- Emphasize the importance of completing the full course of treatment to prevent resistance and recurrence.
- Caution patients about potential drug interactions, especially with CYP3A4 inhibitors/substrates and drugs known to prolong the QT interval.
- Advise on taking erythromycin stearate on an empty stomach for better absorption, if applicable.
Patient Guidelines
- Complete the entire course of medication as prescribed by your doctor, even if your symptoms improve earlier.
- Do not share this medicine with others, even if they have similar symptoms.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Erythromycin generally does not impair the ability to drive or operate machinery. However, rarely, some individuals may experience dizziness, which could affect these activities. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid alcohol consumption during the course of treatment as it may worsen gastrointestinal side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.