Esoprol
Generic Name
Esomeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esoprol 20 mg capsule | ৳ 5.00 | ৳ 50.00 |
| esoprol 40 mg capsule | ৳ 8.00 | ৳ 64.00 |
| esoprol 40 mg injection | ৳ 100.00 | N/A |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat gastroesophageal reflux disease (GERD), ulcers, and other conditions involving excessive stomach acid.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily for 7-10 days (with appropriate antibiotics).
Elderly
No specific dose adjustment is needed for elderly patients.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Oral capsules should be swallowed whole with water, at least one hour before a meal. Do not chew or crush. IV injection is administered by healthcare professionals.
Mechanism of Action
Esomeprazole selectively inhibits the H+/K+-ATPase enzyme system (proton pump) on the secretory surface of the gastric parietal cell, thereby blocking the final step of acid production.
Pharmacokinetics
Onset
Onset of acid suppression within 1 hour.
Excretion
Approximately 80% of a dose is excreted as metabolites in the urine and the remainder in the feces.
Half life
Plasma elimination half-life is approximately 1 to 1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 50% after a single 20 mg oral dose, increasing to 68% after repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole or any components of the formulation, or to other substituted benzimidazoles.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time.
Nelfinavir
Reduced nelfinavir levels.
Tacrolimus
May increase tacrolimus levels.
Clopidogrel
May reduce antiplatelet effect.
Methotrexate
May increase methotrexate levels, leading to toxicity.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include drowsiness, tachycardia, nausea, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if esomeprazole is excreted in human milk; caution is advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole or any components of the formulation, or to other substituted benzimidazoles.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time.
Nelfinavir
Reduced nelfinavir levels.
Tacrolimus
May increase tacrolimus levels.
Clopidogrel
May reduce antiplatelet effect.
Methotrexate
May increase methotrexate levels, leading to toxicity.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include drowsiness, tachycardia, nausea, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if esomeprazole is excreted in human milk; caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of esomeprazole in various acid-related disorders.
Lab Monitoring
- Magnesium levels (for patients on long-term therapy)
- Liver function tests (in patients with severe hepatic impairment)
Doctor Notes
- Consider potential drug interactions, especially with clopidogrel and methotrexate.
- For long-term use, monitor magnesium levels and assess bone health.
Patient Guidelines
- Take Esoprol exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double dose.
Driving Precautions
Esomeprazole is generally considered safe for driving, but if you experience dizziness or visual disturbances, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty, acidic foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Elevate the head of your bed when sleeping.
- Maintain a healthy weight.
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Global Brand Names
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