Esosic
Generic Name
Esomeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esosic 20 mg capsule | ৳ 7.50 | ৳ 75.00 |
Description
Overview of the medicine
Esosic 20 mg Capsule contains Esomeprazole, a proton pump inhibitor used to reduce the amount of acid produced in the stomach. It is effective in treating conditions like GERD, ulcers, and other acid-related digestive issues.
Uses & Indications
Dosage
Adults
Usually 20 mg or 40 mg once daily, depending on the condition. For GERD, 20-40 mg daily for 4-8 weeks. For H. pylori eradication, 20 mg twice daily for 7-14 days.
Elderly
No specific dose adjustment is required for elderly patients.
Renal_impairment
No dose adjustment is needed for patients with renal impairment.
How to Take
Take the capsule whole with water at least one hour before a meal. Do not chew or crush the capsule.
Mechanism of Action
Esomeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby blocking the final step in acid secretion and reducing gastric acidity.
Pharmacokinetics
Onset
Acid secretion inhibition occurs within 1 hour, with full therapeutic effect achieved within 2-3 days of daily dosing.
Excretion
Approximately 80% of the dose is excreted as metabolites in the urine, and the remaining 20% in the feces.
Half life
Plasma elimination half-life is approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached within 1-2 hours. Bioavailability is approximately 50-68% (first dose) and increases with repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and to a lesser extent by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin (caution in elderly or renal impaired patients).
Warfarin
Increased INR and prothrombin time, leading to increased risk of bleeding.
Tacrolimus
Increased systemic exposure of tacrolimus.
Clopidogrel
Reduced antiplatelet effect of clopidogrel, increasing cardiovascular risk.
Methotrexate
Increased and prolonged elevation of serum methotrexate and/or its metabolite, leading to potential toxicity.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
There is limited experience with overdose. Management should be symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Consult a doctor. It is unknown if esomeprazole is excreted in human milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin (caution in elderly or renal impaired patients).
Warfarin
Increased INR and prothrombin time, leading to increased risk of bleeding.
Tacrolimus
Increased systemic exposure of tacrolimus.
Clopidogrel
Reduced antiplatelet effect of clopidogrel, increasing cardiovascular risk.
Methotrexate
Increased and prolonged elevation of serum methotrexate and/or its metabolite, leading to potential toxicity.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
There is limited experience with overdose. Management should be symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Consult a doctor. It is unknown if esomeprazole is excreted in human milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture when stored properly.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety for various acid-related disorders. Studies have shown superior efficacy over omeprazole in some indications.
Lab Monitoring
- No routine lab monitoring is generally required. However, magnesium levels may be monitored in patients on long-term treatment due to risk of hypomagnesemia.
Doctor Notes
- Exclude malignancy, especially in patients with 'alarm symptoms' (e.g., dysphagia, weight loss, persistent vomiting), before initiating Esomeprazole.
- Consider the lowest effective dose for the shortest duration necessary to control symptoms.
- Advise patients on potential long-term risks with PPIs, especially hypomagnesemia and bone fracture risk.
- Review the need for continued PPI therapy periodically.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not chew, crush, or break the capsule; swallow it whole.
- Take the medicine at least one hour before a meal.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Esosic generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Avoid spicy foods, excessive caffeine, and alcohol as these can aggravate acid reflux. Quit smoking if you smoke, as it can worsen GERD symptoms.
- Maintain a healthy weight and elevate the head of your bed to reduce nighttime reflux.
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